Adverse Drug Reaction Classification System

ADR Ontology
ADR Term Type IIa hyperlipidaemia
ADR ID BADD_A04408
ADR Hierarchy
03      Congenital, familial and genetic disorders
03.08      Metabolic and nutritional disorders congenital
03.08.08      Inborn errors of lipid metabolism
03.08.08.001      Type IIa hyperlipidaemia
14      Metabolism and nutrition disorders
14.08      Lipid metabolism disorders
14.08.01      Elevated cholesterol
14.08.01.002      Type IIa hyperlipidaemia
Description A group of familial disorders characterized by elevated circulating cholesterol contained in either LOW-DENSITY LIPOPROTEINS alone or also in VERY-LOW-DENSITY LIPOPROTEINS (pre-beta lipoproteins). | Type IIb hyperlipoproteinemia is caused by mutation in the receptor-binding domain of APOLIPOPROTEIN B-100 which is a major component of LOW-DENSITY LIPOPROTEINS and VERY-LOW-DENSITY LIPOPROTEINS resulting in reduced clearance of these lipoproteins. It is characterized by both hypercholesterolemia and HYPERTRIGLYCERIDEMIA (combined hyperlipidemia). | Hypercholesterolemia that is caused by mutation in the LOW DENSITY LIPOPROTEIN RECEPTOR gene. This receptor defect prevents LDL binding to the cell membrane and uptake of cholesterol which normally suppresses further cholesterol synthesis. [MeSH]
MedDRA Code 10045261
MeSH ID D006938
ADR Severity Grade (FAERS) Not Available
ADR Severity Grade (CTCAE) Not Available
Synonym
Familial hyperlipidaemia | Fredrickson Type IIa hyperlipidaemia | Fredrickson Type IIa hyperlipoproteinaemia | Fredrickson Type IIa lipidaemia | Pure hypercholesterolaemia | Pure hypercholesterolemia | Type IIa hyperlipidaemia | Type IIa hyperlipidemia | Familial hypercholesterolaemia | Familial hypercholesterolemia | Familial hyperlipidemia | Heterozygous familial hypercholesterolemia | Homozygous familial hypercholesterolemia | Heterozygous familial hypercholesterolaemia | Homozygous familial hypercholesterolaemia | Fredrickson Type IIa hyperlipidemia | Fredrickson Type IIa hyperlipoproteinemia | Fredrickson Type IIa lipidemia | Type IIa hyperlipoproteinaemia | Type IIa hyperlipoproteinemia | Autosomal recessive hypercholesterolemia | Autosomal recessive hypercholesterolaemia | Hyperlipoproteinemia Type II | Hyperlipoproteinemia Type IIs | Hyper-Low Density Lipoproteinemia | Density Lipoproteinemia, Hyper-Low | Density Lipoproteinemias, Hyper-Low | Hyper Low Density Lipoproteinemia | Hyper-Low Density Lipoproteinemias | Lipoproteinemia, Hyper-Low Density | Lipoproteinemias, Hyper-Low Density | Hyper-Low-Density-Lipoproteinemia | Hyper-Low-Density-Lipoproteinemias | Hyperlipoproteinemia, Type II | Hyperlipoproteinemias, Type II | Type II Hyperlipoproteinemia | Type II Hyperlipoproteinemias | Hypercholesterolemia, Essential | Essential Hypercholesterolemia | Essential Hypercholesterolemias | Hypercholesterolemias, Essential | Hypercholesterolemia, Familial | Familial Hypercholesterolemia | Familial Hypercholesterolemias | Hypercholesterolemias, Familial | Hypercholesterolemic Xanthomatosis, Familial | Familial Hypercholesterolemic Xanthomatoses | Familial Hypercholesterolemic Xanthomatosis | Hypercholesterolemic Xanthomatoses, Familial | Xanthomatoses, Familial Hypercholesterolemic | Xanthomatosis, Familial Hypercholesterolemic | Hyperlipoproteinemia Type 2 | Hyperlipoproteinemia Type 2s | Type 2, Hyperlipoproteinemia | Hyper-beta-Lipoproteinemia | Hyper beta Lipoproteinemia | Hyper-beta-Lipoproteinemias | Hyperbetalipoproteinemia | Hyperbetalipoproteinemias | Hyperlipoproteinemia Type IIb | Hyperlipoproteinemia Type IIbs | Hypercholesterolemia, Autosomal Dominant, Type B | Familial Combined Hyperlipoproteinemia | Combined Hyperlipoproteinemia, Familial | Combined Hyperlipoproteinemias, Familial | Familial Combined Hyperlipoproteinemias | Hyperlipoproteinemia, Familial Combined | Hyperlipoproteinemias, Familial Combined | Apolipoprotein B-100, Familial Defective | Apolipoprotein B 100, Familial Defective | Apolipoprotein B-100, Familial Ligand-Defective | Apolipoprotein B 100, Familial Ligand Defective | Hyperlipoproteinemia Type IIa | Hyperlipoproteinemia Type IIas | Hyperlipoproteinemia, Type IIa | Hyperlipoproteinemias, Type IIa | Type IIa Hyperlipoproteinemia | Type IIa Hyperlipoproteinemias | Hypercholesterolemia, Autosomal Dominant | Autosomal Dominant Hypercholesterolemia | Autosomal Dominant Hypercholesterolemias | Dominant Hypercholesterolemia, Autosomal | Dominant Hypercholesterolemias, Autosomal | Hypercholesterolemias, Autosomal Dominant | LDL Receptor Disorder | Disorder, LDL Receptor | Disorders, LDL Receptor | LDL Receptor Disorders | Receptor Disorder, LDL | Receptor Disorders, LDL
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D00864Ezetimibe--
BADD_D00948Fluvastatin--
BADD_D00949Fluvastatin sodium--
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