Adverse Drug Reaction Classification System

         

ADR Ontology
ADR Term Brain oedema
ADR ID BADD_A04766
ADR Hierarchy
12      Injury, poisoning and procedural complications
12.01      Injuries NEC
12.01.10      Cerebral injuries NEC
12.01.10.010      Brain oedema
17      Nervous system disorders
17.07      Increased intracranial pressure and hydrocephalus
17.07.02      Increased intracranial pressure disorders
17.07.02.003      Brain oedema
Description Increased intracellular or extracellular fluid in brain tissue. Cytotoxic brain edema (swelling due to increased intracellular fluid) is indicative of a disturbance in cell metabolism, and is commonly associated with hypoxic or ischemic injuries (see HYPOXIA, BRAIN). An increase in extracellular fluid may be caused by increased brain capillary permeability (vasogenic edema), an osmotic gradient, local blockages in interstitial fluid pathways, or by obstruction of CSF flow (e.g., obstructive HYDROCEPHALUS). (From Childs Nerv Syst 1992 Sep; 8(6):301-6) [MeSH]
MedDRA Code 10048962
MeSH ID D001929
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE)
Synonym
Brain edema | Cerebral edema | Cerebral oedema | Edema brain | Edema cerebral | Oedema cerebral | Brain oedema | Oedema brain | Cerebellar edema | Cerebellar oedema | Brain swelling | Malignant brain edema | Malignant brain oedema | Brain Edema | Edema, Brain | Intracranial Edema | Edema, Intracranial | Brain Swelling | Brain Swellings | Swelling, Brain | Vasogenic Cerebral Edema | Cerebral Edemas, Vasogenic | Edema, Vasogenic Cerebral | Cerebral Edema, Vasogenic | Cytotoxic Cerebral Edema | Cerebral Edema, Cytotoxic | Edema, Cytotoxic Cerebral | Vasogenic Brain Edema | Brain Edema, Vasogenic | Edema, Vasogenic Brain | Cerebral Edema | Edema, Cerebral | Cytotoxic Brain Edema | Brain Edema, Cytotoxic | Edema, Cytotoxic Brain
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D01445Metoprolol0.000030%
BADD_D01449Metronidazole0.000079%
BADD_D01476Mirtazapine0.000080%
BADD_D01498Morphine0.001615%
BADD_D01506Muromonab-cd3--
BADD_D01567Nilotinib--
BADD_D01599Olanzapine0.002315%
BADD_D01637Oxcarbazepine0.000170%
BADD_D01679Paroxetine--
BADD_D01687Pazopanib0.000336%
BADD_D01735Pergolide--
BADD_D01736Pergolide mesylate--
BADD_D01743Perphenazine--
BADD_D01752Phenobarbital0.000325%
BADD_D01765Phenytoin--
BADD_D01817Pramipexole--
BADD_D01818Pramipexole dihydrochloride--
BADD_D01831Prednisolone0.000070%
BADD_D01834Prednisone0.000031%
BADD_D01835Pregabalin--
BADD_D01848Prochlorperazine--
BADD_D01849Prochlorperazine edisylate--
BADD_D01850Prochlorperazine maleate--
BADD_D01854Promethazine0.000038%
BADD_D01858Propagermanium--
BADD_D01864Propofol0.000268%
BADD_D01888Quetiapine0.000136%
BADD_D01922Regorafenib0.000336%
BADD_D01951Risperidone0.001455%
BADD_D01954Rivaroxaban0.001203%
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