Adverse Drug Reaction Classification System

ADR Ontology
ADR Term Periventricular leukomalacia
ADR ID BADD_A05157
ADR Hierarchy
17      Nervous system disorders
17.13      Encephalopathies
17.13.02      Encephalopathies NEC
17.13.02.005      Periventricular leukomalacia
18      Pregnancy, puerperium and perinatal conditions
18.04      Neonatal and perinatal conditions
18.04.07      Neonatal cardiovascular disorders (excl cardiorespiratory arrest)
18.04.07.003      Periventricular leukomalacia
Description Degeneration of white matter adjacent to the CEREBRAL VENTRICLES following cerebral hypoxia or BRAIN ISCHEMIA in neonates. The condition primarily affects white matter in the perfusion zone between superficial and deep branches of the MIDDLE CEREBRAL ARTERY. Clinical manifestations include VISION DISORDERS; CEREBRAL PALSY; PARAPLEGIA; SEIZURES; and cognitive disorders. (From Adams et al., Principles of Neurology, 6th ed, p1021; Joynt, Clinical Neurology, 1997, Ch4, pp30-1) [MeSH]
MedDRA Code 10052594
MeSH ID D007969
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE) Not Available
Synonym
Periventricular leukomalacia | Leukomalacia | Leukomalacia, Periventricular | Periventricular Leukomalacia | Leukomalacias, Periventricular | Periventricular Leukomalacias | Encephalomalacia, Periventricular | Encephalomalacias, Periventricular | Periventricular Encephalomalacia | Periventricular Encephalomalacias | Leucomalacia, Periventricular | Leucomalacias, Periventricular | Periventricular Leucomalacia | Periventricular Leucomalacias | Neonatal Cerebral Leukomalacia | Cerebral Leukomalacia, Neonatal | Cerebral Leukomalacias, Neonatal | Leukomalacia, Neonatal Cerebral | Leukomalacias, Neonatal Cerebral | Neonatal Cerebral Leukomalacias | Cystic Periventricular Leukomalacia | Cystic Periventricular Leukomalacias | Leukomalacia, Cystic Periventricular | Leukomalacias, Cystic Periventricular | Periventricular Leukomalacia, Cystic | Periventricular Leukomalacias, Cystic
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D00342Calfactant--
BADD_D01086Hydrocortisone0.000046%
BADD_D01120Ibuprofen--
BADD_D01156Indomethacin0.000528%
BADD_D01265Levetiracetam0.000119%
BADD_D01574Nitric oxide--
BADD_D01952Ritonavir0.000735%
BADD_D02010Sertraline0.000013%
BADD_D02394Zolpidem0.000089%
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