| ADR Ontology |
| ADR Term |
Argininosuccinate synthetase deficiency |
| ADR ID |
BADD_A05569 |
| ADR Hierarchy |
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| Description |
A group of diseases related to a deficiency of the enzyme ARGININOSUCCINATE SYNTHASE which causes an elevation of serum levels of CITRULLINE. In neonates, clinical manifestations include lethargy, hypotonia, and SEIZURES. Milder forms also occur. Childhood and adult forms may present with recurrent episodes of intermittent weakness, lethargy, ATAXIA, behavioral changes, and DYSARTHRIA. (From Menkes, Textbook of Child Neurology, 5th ed, p49) [MeSH] |
| MedDRA Code |
10058298 |
| MeSH ID |
D020159
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ADR Severity Grade (FAERS)
|
Not Available
|
|
ADR Severity Grade (CTCAE)
|
Not Available
|
| Synonym |
| Argininosuccinate synthetase deficiency | Citrullinemia | Citrullinaemia | Citrullinemia type I | Citrullinaemia type I | Citrullinemias | Argininosuccinate Synthetase Deficiency | Argininosuccinate Synthetase Deficiencies | Deficiencies, Argininosuccinate Synthetase | Deficiency, Argininosuccinate Synthetase | Argininosuccinic Acid Synthase Deficiency Disease | Argininosuccinic Acid Synthetase Deficiency | Argininosuccinic Acid Synthetase Deficiency Disease | Citrullinemia, Type I | Citrullinemia 1 | Citrullinemia Type 1 | Type 1, Citrullinemia | Citrullinemia, Classic | Citrullinemias, Classic | Classic Citrullinemia | Classic Citrullinemias | Citrullinuria | Citrullinurias | Deficiency Disease, Argininosuccinate Synthase | Deficiency Disease, Argininosuccinic Acid Synthase | Argininosuccinate Synthase Deficiency Disease | ASS Deficiency | ASS Deficiencies | Deficiencies, ASS | Deficiency, ASS | Argininosuccinic Acid Synthetase Deficiency Disease, Partial | Deficiency, Argininosuccinic Acid Synthetase, Partial | Partial Argininosuccinic Acid Synthetase Deficiency Disease | Citrullinemia, Late-Onset | Citrullinemia, Late Onset | Citrullinemias, Late-Onset | Late-Onset Citrullinemia | Late-Onset Citrullinemias | Argininosuccinic Acid Synthetase Deficiency, Complete | Deficiency, Argininosuccinic Acid Synthetase, Complete | Complete Argininosuccinic Acid Synthetase Deficiency Disease | Citrullinemia, Classical | Citrullinemias, Classical | Classical Citrullinemia | Classical Citrullinemias | Citrullinemia, Neonatal | Citrullinemias, Neonatal | Neonatal Citrullinemia | Neonatal Citrullinemias |
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| Drugs Leading to the ADR |
| Drug ID | Drug Name | ADR Frequency (FAERS) | ADR Severity Grade (FAERS) | | BADD_D01054 | Haloperidol | - | - |
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