Adverse Drug Reaction Classification System

ADR Ontology
ADR Term Restless legs syndrome
ADR ID BADD_A05624
ADR Hierarchy
15      Musculoskeletal and connective tissue disorders
15.05      Muscle disorders
15.05.03      Muscle related signs and symptoms NEC
15.05.03.012      Restless legs syndrome
17      Nervous system disorders
17.02      Neurological disorders NEC
17.02.07      Sensory abnormalities NEC
17.02.07.008      Restless legs syndrome
Description A disorder characterized by aching or burning sensations in the lower and rarely the upper extremities that occur prior to sleep or may awaken the patient from sleep. [MeSH]
MedDRA Code 10058920
MeSH ID D012148
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE) Not Available
Synonym
Legs restless | Restless leg syndrome | Restless legs | Syndrome restless legs | Restless legs syndrome | Secondary restless legs syndrome | Willis-Ekbom disease | Restless Legs Syndrome | Restless Legs | Willis Ekbom Disease | Disease, Willis Ekbom | Wittmaack-Ekbom Syndrome | Syndrome, Wittmaack-Ekbom | Willis-Ekbom Disease | Disease, Willis-Ekbom | Willis-Ekbom Syndrome | Syndrome, Willis-Ekbom | Wittmaack Ekbom Syndrome | Syndrome, Wittmaack Ekbom | Restless Leg Syndrome | Syndrome, Restless Leg | Willis Ekbom Syndrome | Syndrome, Willis Ekbom
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D01645Oxycodone--
BADD_D01654Palbociclib0.001724%
BADD_D01656Paliperidone0.013659%
BADD_D01679Paroxetine--
BADD_D01680Paroxetine hydrochloride--
BADD_D01681Paroxetine hydrochloride hemihydrate--
BADD_D01683Paroxetine mesylate--
BADD_D01804Posaconazole--
BADD_D01817Pramipexole0.007209%
BADD_D01835Pregabalin0.002738%
BADD_D01854Promethazine0.000131%
BADD_D01867Propranolol0.000144%
BADD_D01888Quetiapine0.001292%
BADD_D01889Quetiapine fumarate--
BADD_D01933Ribavirin0.015823%
BADD_D01951Risperidone0.001249%
BADD_D01954Rivaroxaban--
BADD_D01956Rivastigmine tartrate--
BADD_D01971Rosuvastatin0.000046%
BADD_D01973Rotigotine0.005650%
BADD_D01978Ruxolitinib0.000604%
BADD_D02006Selexipag0.000600%
BADD_D02010Sertraline0.000228%
BADD_D02026Simvastatin0.000033%
BADD_D02031Sitaxentan--
BADD_D02047Sodium oxybate0.012098%
BADD_D02053Sofosbuvir0.001101%
BADD_D02107Tafamidis0.001723%
BADD_D02115Tapentadol0.000637%
BADD_D02118Tasimelteon0.000444%
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