| ADR Ontology |
| ADR Term |
Apoptosis |
| ADR ID |
BADD_A05675 |
| ADR Hierarchy |
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| Description |
One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth. | Apoptosis that is triggered via cell stress and mitochondrial damage. | Apoptosis that is triggered via CELL SURFACE RECEPTORS such as TUMOR NECROSIS FACTOR RECEPTORS and DEATH DOMAIN RECEPTORS. [MeSH] |
| MedDRA Code |
10059512 |
| MeSH ID |
D017209
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ADR Severity Grade (FAERS)
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ADR Severity Grade (CTCAE)
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Not Available
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| Synonym |
| Intestinal villi apoptosis | Duodenal villi apoptosis | Apoptotic DNA damage | Apoptosis | Programmed Cell Death, Type I | Apoptosis, Intrinsic Pathway | Apoptoses, Intrinsic Pathway | Intrinsic Pathway Apoptoses | Intrinsic Pathway Apoptosis | Apoptosis, Extrinsic Pathway | Apoptoses, Extrinsic Pathway | Extrinsic Pathway Apoptoses | Extrinsic Pathway Apoptosis |
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| Drugs Leading to the ADR |
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