Adverse Drug Reaction Classification System

ADR Ontology
ADR Term Hyperinsulinism
ADR ID BADD_A05819
ADR Hierarchy
05      Endocrine disorders
05.06      Glucose metabolism disorders (incl diabetes mellitus)
05.06.03      Hypoglycaemic conditions NEC
05.06.03.007      Hyperinsulinism
14      Metabolism and nutrition disorders
14.06      Glucose metabolism disorders (incl diabetes mellitus)
14.06.03      Hypoglycaemic conditions NEC
14.06.03.007      Hyperinsulinism
Description A syndrome with excessively high INSULIN levels in the BLOOD. It may cause HYPOGLYCEMIA. Etiology of hyperinsulinism varies, including hypersecretion of a beta cell tumor (INSULINOMA); autoantibodies against insulin (INSULIN ANTIBODIES); defective insulin receptor (INSULIN RESISTANCE); or overuse of exogenous insulin or HYPOGLYCEMIC AGENTS. | A GLUCOSE-induced HYPERINSULINEMIA, a marker of insulin-resistant state. It is a mechanism to compensate for reduced sensitivity to insulin. [MeSH]
MedDRA Code 10061211
MeSH ID D006946
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE) Not Available
Synonym
Hyperinsulinism NOS | Hyperinsulinism, other | Other hyperinsulinism | Hyperinsulinism | Hyperinsulinemia | Exogenous Hyperinsulinism | Hyperinsulinism, Exogenous | Compensatory Hyperinsulinemia | Hyperinsulinemia, Compensatory | Endogenous Hyperinsulinism | Hyperinsulinism, Endogenous
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D00079Alogliptin0.000399%
BADD_D00165Aripiprazole--
BADD_D00576Danazol--
BADD_D01563Nicotinate--
BADD_D01599Olanzapine0.000210%
BADD_D01656Paliperidone--
BADD_D01951Risperidone--
BADD_D02060Sotalol--
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ADReCS-Target
ADR Term Drug Name Target