Adverse Drug Reaction Classification System

ADR Ontology
ADR Term Parkinson's disease
ADR ID BADD_A05941
ADR Hierarchy
17      Nervous system disorders
17.01      Movement disorders (incl parkinsonism)
17.01.05      Parkinson's disease and parkinsonism
17.01.05.010      Parkinson's disease
Description A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency to fall backwards), rigidity, stooped posture, slowness of voluntary movements, and a masklike facial expression. Pathologic features include loss of melanin containing neurons in the substantia nigra and other pigmented nuclei of the brainstem. LEWY BODIES are present in the substantia nigra and locus coeruleus but may also be found in a related condition (LEWY BODY DISEASE, DIFFUSE) characterized by dementia in combination with varying degrees of parkinsonism. (Adams et al., Principles of Neurology, 6th ed, p1059, pp1067-75) [MeSH]
MedDRA Code 10061536
MeSH ID D010300
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE) Not Available
Synonym
Disease Parkinson's | Palsy shaking | Paralysis agitans | Parkinson's dis | Parkinson's disease aggravated | Parkinson's disease NOS | Parkinson's disease | End stage Parkinson's disease | Parkinson Disease | Idiopathic Parkinson's Disease | Lewy Body Parkinson Disease | Lewy Body Parkinson's Disease | Primary Parkinsonism | Parkinsonism, Primary | Parkinson Disease, Idiopathic | Parkinson's Disease | Parkinson's Disease, Idiopathic | Parkinson's Disease, Lewy Body | Idiopathic Parkinson Disease | Paralysis Agitans
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D02265Travoprost0.000184%
BADD_D02331Valsartan0.000159%
BADD_D02346Venlafaxine0.000113%
BADD_D02375Water--
BADD_D02392Zoledronic acid--
BADD_D02412Octreotide--
BADD_D02439Levodopa0.011227%
BADD_D02441Rasagiline0.017374%
BADD_D02443Tiotropium--
BADD_D02445Solifenacin0.000608%
BADD_D02451Pimavanserin0.024630%
BADD_D02484Istradefylline0.005503%
BADD_D02491Valbenazine0.006568%
BADD_D02507Deutetrabenazine0.000808%
BADD_D02569Magnesium0.000294%
BADD_D02574Molnupiravir0.000282%
BADD_D02576Opicapone0.000734%
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ADReCS-Target
ADR Term Drug Name Target