Adverse Drug Reaction Classification System

ADR Ontology
ADR Term Complex regional pain syndrome
ADR ID BADD_A06235
ADR Hierarchy
12      Injury, poisoning and procedural complications
12.01      Injuries NEC
12.01.12      Nerve injuries NEC
12.01.12.004      Complex regional pain syndrome
17      Nervous system disorders
17.02      Neurological disorders NEC
17.02.07      Sensory abnormalities NEC
17.02.07.010      Complex regional pain syndrome
Description A complex regional pain syndrome characterized by burning pain and marked sensitivity to touch (HYPERESTHESIA) in the distribution of an injured peripheral nerve. Autonomic dysfunction in the form of sudomotor (i.e., sympathetic innervation to sweat glands), vasomotor, and trophic skin changes may also occur. (Adams et al., Principles of Neurology, 6th ed, p1359) [MeSH]
MedDRA Code 10064332
MeSH ID D002422; D012019
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE) Not Available
Synonym
Algoneurodystrophy | Causalgia | Causalgia of lower limb | Reflex sympathetic dystrophy | Reflex sympathetic dystrophy of other specified site | Reflex sympathetic dystrophy of the lower limb | Reflex sympathetic dystrophy of the upper limb | Reflex sympathetic dystrophy, unspecified | Shoulder hand syndrome | Sudeck's atrophy | Algodystrophy | Complex regional pain syndrome | Complex regional pain syndrome Type I | Complex regional pain syndrome Type II | Sudeck-Leriche syndrome | Steinbrocker syndrome | Type II Complex Regional Pain Syndrome | CRPS Type II | Deafferentation Pain | Pain, Deafferentation | Causalgia Syndrome | Causalgia Syndromes | Syndrome, Causalgia | Syndromes, Causalgia | Complex Regional Pain Syndrome Type II
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D00066Alendronic acid0.000110%
BADD_D00142Anastrozole0.000159%
BADD_D00356Carbamazepine0.000279%
BADD_D00364Carboplatin0.000112%
BADD_D00407Cefuroxime0.000215%
BADD_D00659Dicyclomine--
BADD_D00858Everolimus0.000153%
BADD_D00981Gabapentin0.000026%
BADD_D01136Imatinib0.000168%
BADD_D01252Leflunomide0.000428%
BADD_D01275Levofloxacin0.000316%
BADD_D01445Metoprolol0.000007%
BADD_D01645Oxycodone0.000062%
BADD_D01817Pramipexole0.000159%
BADD_D01835Pregabalin0.000394%
BADD_D02047Sodium oxybate0.001046%
BADD_D02105Tacrolimus0.000446%
BADD_D02151Temsirolimus--
BADD_D02192Thalidomide--
BADD_D02373Warfarin0.000042%
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