Adverse Drug Reaction Classification System

         

ADR Ontology
ADR Term Kounis syndrome
ADR ID BADD_A06553
ADR Hierarchy
02      Cardiac disorders
02.02      Coronary artery disorders
02.02.02      Ischaemic coronary artery disorders
02.02.02.020      Kounis syndrome
10      Immune system disorders
10.01      Allergic conditions
10.01.03      Allergic conditions NEC
10.01.03.037      Kounis syndrome
24      Vascular disorders
24.04      Arteriosclerosis, stenosis, vascular insufficiency and necrosis
24.04.04      Coronary necrosis and vascular insufficiency
24.04.04.020      Kounis syndrome
Description A disorder of cardiac function secondary to hypersensitivity reactions. It is characterized by coexistence of acute coronary syndromes and cardiac MAST CELL and PLATELET ACTIVATION. It may be induced by exposure to drugs (e.g., antibiotics, anesthetics, contrast media), food, and environmental triggers (e.g., insect bites and stings, poison ivy). [MeSH]
MedDRA Code 10069167
MeSH ID D000074962
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE) Not Available
Synonym
Kounis syndrome | Vasospastic allergic angina | Kounis syndrome type I | Kounis syndrome type II | Kounis Syndrome | Allergic Angina Syndrome | Allergic Angina Syndromes | Allergic Acute Coronary Syndrome | Allergic Myocardial Infarction | Allergic Myocardial Infarctions | Myocardial Infarction, Allergic
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D00023Acetaminophen--
BADD_D00033Acetylsalicylic acid0.000044%
BADD_D00115Amiodarone0.000135%
BADD_D00129Amoxicillin0.000062%
BADD_D00349Capecitabine0.000112%
BADD_D00382Cefazolin0.000243%
BADD_D00399Ceftazidime0.000049%
BADD_D00405Ceftriaxone0.037881%
BADD_D00407Cefuroxime0.002504%
BADD_D00410Celecoxib0.000124%
BADD_D00480Clarithromycin0.001898%
BADD_D00483Clindamycin0.000060%
BADD_D00504Clopidogrel0.000043%
BADD_D00653Diclofenac0.000384%
BADD_D00718Doxazosin0.000226%
BADD_D00782Epinephrine0.000565%
BADD_D00784Epirubicin0.000112%
BADD_D00912Fluconazole0.000112%
BADD_D00931Fluorouracil0.000184%
BADD_D01120Ibuprofen0.000009%
BADD_D01180Iohexol0.010670%
BADD_D01182Iopromide0.017783%
BADD_D01213Isotretinoin0.000772%
BADD_D01231Ketoprofen0.003361%
BADD_D01245Lansoprazole0.000348%
BADD_D01275Levofloxacin0.000822%
BADD_D01395Mersyndol--
BADD_D01442Metoclopramide0.000686%
BADD_D01445Metoprolol0.000047%
BADD_D01449Metronidazole0.000053%
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