Adverse Drug Reaction Classification System

         

ADR Ontology
ADR Term Osmotic demyelination syndrome
ADR ID BADD_A06561
ADR Hierarchy
17      Nervous system disorders
17.16      Demyelinating disorders
17.16.02      Demyelinating disorders NEC
17.16.02.004      Osmotic demyelination syndrome
Description A demyelinating condition affecting the PONS and characterized clinically by an acute progressive QUADRIPLEGIA; DYSARTHRIA; DYSPHAGIA; and alterations of consciousness. Pathologic features include prominent demyelination in the central PONS with sparing of axons and neurons. This condition is usually associated with systemic disorders such as HYPONATREMIA; chronic ALCOHOLISM; LIVER FAILURE; severe BURNS; malignant NEOPLASMS; hemorrhagic PANCREATITIS; HEMODIALYSIS; and SEPSIS. The rapid medical correction of hyponatremia has been cited as a cause of this condition. (From Adams et al., Principles of Neurology, 6th ed, pp1125-6) [MeSH]
MedDRA Code 10069350
MeSH ID D017590
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE) Not Available
Synonym
Central pontine myelinolysis | Central pontine myelolysis | Osmotic demyelination syndrome | Extrapontine myelinolysis | Myelinolysis, Central Pontine | Pontine Myelinolysis, Central | Myelinoclasis, Central Pontine | Central Pontine Myelinoclasis | Central Pontine Myelinolysis | Extrapontine Myelinolysis | Extrapontine Myelinolyses | Myelinolyses, Extrapontine | Myelinolysis, Extrapontine | Extrapontine Myelinoclasis | Extrapontine Myelinoclases | Myelinoclases, Extrapontine | Myelinoclasis, Extrapontine
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D00033Acetylsalicylic acid0.000022%
BADD_D00526Conivaptan--
BADD_D00616Desmopressin0.001283%
BADD_D00734Duloxetine0.000067%
BADD_D01149Indapamide0.000754%
BADD_D01240Lactulose0.000268%
BADD_D01275Levofloxacin0.000127%
BADD_D01304Lithium cation0.000192%
BADD_D01633Oxaliplatin0.000280%
BADD_D02010Sertraline0.000019%
BADD_D02105Tacrolimus0.004010%
BADD_D02246Tolvaptan0.000523%
BADD_D02247Topiramate0.000251%
BADD_D02473Sodium chloride0.002172%
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