Adverse Drug Reaction Classification System

         

ADR Ontology
ADR Term Hypoxic-ischaemic encephalopathy
ADR ID BADD_A06611
ADR Hierarchy
17      Nervous system disorders
17.13      Encephalopathies
17.13.02      Encephalopathies NEC
17.13.02.006      Hypoxic-ischaemic encephalopathy
22      Respiratory, thoracic and mediastinal disorders
22.02      Respiratory disorders NEC
22.02.02      Conditions associated with abnormal gas exchange
22.02.02.011      Hypoxic-ischaemic encephalopathy
24      Vascular disorders
24.04      Arteriosclerosis, stenosis, vascular insufficiency and necrosis
24.04.06      Cerebrovascular and spinal necrosis and vascular insufficiency
24.04.06.021      Hypoxic-ischaemic encephalopathy
Description A reduction in brain oxygen supply due to ANOXEMIA (a reduced amount of oxygen being carried in the blood by HEMOGLOBIN), or to a restriction of the blood supply to the brain, or both. Severe hypoxia is referred to as anoxia, and is a relatively common cause of injury to the central nervous system. Prolonged brain anoxia may lead to BRAIN DEATH or a PERSISTENT VEGETATIVE STATE. Histologically, this condition is characterized by neuronal loss which is most prominent in the HIPPOCAMPUS; GLOBUS PALLIDUS; CEREBELLUM; and inferior olives. [MeSH]
MedDRA Code 10070511
MeSH ID D002534; D020925; D002545
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE) Not Available
Synonym
Encephalopathy pulmonary | Hypoxic encephalopathy | Hypercapnic encephalopathy | Anoxic encephalopathy | Hypoxic-ischaemic encephalopathy | Hypoxic-ischemic encephalopathy | Ischemic encephalopathy | Ischaemic encephalopathy | Hypoxia, Brain | Cerebral Hypoxia | Hypoxia, Cerebral | Brain Hypoxia | Anoxic Brain Damage | Brain Damage, Anoxic | Damage, Anoxic Brain | Anoxic Encephalopathy | Anoxic Encephalopathies | Encephalopathies, Anoxic | Encephalopathy, Anoxic | Hypoxic Brain Damage | Brain Damage, Hypoxic | Damage, Hypoxic Brain | Hypoxic Encephalopathy | Encephalopathy, Hypoxic | Encephalopathies, Hypoxic | Hypoxic Encephalopathies | Anoxia, Brain | Cerebral Anoxia | Anoxia, Cerebral | Brain Anoxia
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D01180Iohexol0.017783%
BADD_D01182Iopromide0.014227%
BADD_D01242Lamivudine0.002024%
BADD_D01243Lamotrigine0.000138%
BADD_D01265Levetiracetam0.000079%
BADD_D01401Metformin0.000019%
BADD_D01405Methadone0.002254%
BADD_D01498Morphine0.000724%
BADD_D01567Nilotinib0.000112%
BADD_D01599Olanzapine0.000842%
BADD_D01636Oxazepam0.001520%
BADD_D01645Oxycodone0.000062%
BADD_D01831Prednisolone0.000035%
BADD_D01852Progesterone0.000125%
BADD_D01864Propofol0.000179%
BADD_D01867Propranolol0.000053%
BADD_D01951Risperidone0.000121%
BADD_D02010Sertraline0.000025%
BADD_D02015Sevoflurane0.000268%
BADD_D02084Sugammadex0.001239%
BADD_D02105Tacrolimus0.000297%
BADD_D02170Testosterone0.000182%
BADD_D02195Theophylline--
BADD_D02214Ticagrelor0.000272%
BADD_D02254Tramadol0.000014%
BADD_D02355Vigabatrin0.000125%
BADD_D02369Voriconazole0.005809%
BADD_D02373Warfarin0.000056%
BADD_D02577Oseltamivir acid0.000248%
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