Adverse Drug Reaction Classification System

ADR Ontology
ADR Term Drug-induced liver injury
ADR ID BADD_A06676
ADR Hierarchy
09      Hepatobiliary disorders
09.01      Hepatic and hepatobiliary disorders
09.01.07      Hepatocellular damage and hepatitis NEC
09.01.07.023      Drug-induced liver injury
12      Injury, poisoning and procedural complications
12.03      Exposures, chemical injuries and poisoning
12.03.01      Poisoning and toxicity
12.03.01.044      Drug-induced liver injury
Description A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug metabolites, herbal and dietary supplements and chemicals from the environment. | INFLAMMATION of the LIVER due to hepatocellular toxicity, caused by drug metabolites and chemicals from the environment. [MeSH]
MedDRA Code 10072268
MeSH ID D056486
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE) Not Available
Synonym
Drug-induced liver disease | Drug-induced hepatitis | Hepatitis allergic drug-induced | Hepatitis drug-induced | Hepatitis toxic drug-induced | Hy's law case | Drug-induced liver injury | DILI | Drug-induced hepatotoxicity | Herb-induced liver injury | Chemical and Drug Induced Liver Injury | Chemically-Induced Liver Toxicity | Chemically Induced Liver Toxicity | Chemically-Induced Liver Toxicities | Liver Toxicities, Chemically-Induced | Liver Toxicity, Chemically-Induced | Toxicities, Chemically-Induced Liver | Toxicity, Chemically-Induced Liver | Drug-Induced Acute Liver Injury | Drug Induced Acute Liver Injury | Liver Injury, Drug-Induced, Acute | Acute Liver Injury, Drug-Induced | Acute Liver Injury, Drug Induced | Hepatitis, Toxic | Toxic Hepatitis | Hepatitides, Toxic | Toxic Hepatitides | Drug-Induced Liver Disease | Disease, Drug-Induced Liver | Diseases, Drug-Induced Liver | Drug Induced Liver Disease | Drug-Induced Liver Diseases | Liver Disease, Drug-Induced | Liver Diseases, Drug-Induced | Drug-Induced Liver Injury | Drug Induced Liver Injury | Drug-Induced Liver Injuries | Injuries, Drug-Induced Liver | Injury, Drug-Induced Liver | Liver Injuries, Drug-Induced | Liver Injury, Drug-Induced | Liver Injury, Drug Induced | Hepatitis, Drug-Induced | Drug-Induced Hepatitides | Drug-Induced Hepatitis | Hepatitides, Drug-Induced | Hepatitis, Drug Induced
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D00349Capecitabine0.001287%
BADD_D00354Captopril0.000732%
BADD_D00356Carbamazepine0.008834%
BADD_D00374Carvedilol0.000041%
BADD_D00376Caspofungin0.000299%
BADD_D00382Cefazolin0.000812%
BADD_D00386Cefepime0.000049%
BADD_D00388Cefixime0.000724%
BADD_D00405Ceftriaxone0.133696%
BADD_D00407Cefuroxime0.001145%
BADD_D00410Celecoxib0.000497%
BADD_D00412Cephalexin0.000077%
BADD_D00414Ceritinib0.000168%
BADD_D00417Cetirizine0.000486%
BADD_D00445Chlorpromazine0.000677%
BADD_D00479Cladribine0.000382%
BADD_D00480Clarithromycin0.001340%
BADD_D00504Clopidogrel0.000235%
BADD_D00509Clotrimazole0.000241%
BADD_D00535Crizotinib--
BADD_D00551Cyclosporine--
BADD_D00560Cytarabine0.000504%
BADD_D00578Dapagliflozin--
BADD_D00580Dapsone0.009350%
BADD_D00581Daptomycin0.000350%
BADD_D00586Darunavir0.001356%
BADD_D00593Decitabine0.000168%
BADD_D00594Deferasirox--
BADD_D00615Desloratadine0.003053%
BADD_D00628Dexlansoprazole--
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