Adverse Drug Reaction Classification System

ADR Ontology
ADR Term Drug-induced liver injury
ADR ID BADD_A06676
ADR Hierarchy
09      Hepatobiliary disorders
09.01      Hepatic and hepatobiliary disorders
09.01.07      Hepatocellular damage and hepatitis NEC
09.01.07.023      Drug-induced liver injury
12      Injury, poisoning and procedural complications
12.03      Exposures, chemical injuries and poisoning
12.03.01      Poisoning and toxicity
12.03.01.044      Drug-induced liver injury
Description A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug metabolites, herbal and dietary supplements and chemicals from the environment. | INFLAMMATION of the LIVER due to hepatocellular toxicity, caused by drug metabolites and chemicals from the environment. [MeSH]
MedDRA Code 10072268
MeSH ID D056486
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE) Not Available
Synonym
Drug-induced liver disease | Drug-induced hepatitis | Hepatitis allergic drug-induced | Hepatitis drug-induced | Hepatitis toxic drug-induced | Hy's law case | Drug-induced liver injury | DILI | Drug-induced hepatotoxicity | Herb-induced liver injury | Chemical and Drug Induced Liver Injury | Chemically-Induced Liver Toxicity | Chemically Induced Liver Toxicity | Chemically-Induced Liver Toxicities | Liver Toxicities, Chemically-Induced | Liver Toxicity, Chemically-Induced | Toxicities, Chemically-Induced Liver | Toxicity, Chemically-Induced Liver | Drug-Induced Acute Liver Injury | Drug Induced Acute Liver Injury | Liver Injury, Drug-Induced, Acute | Acute Liver Injury, Drug-Induced | Acute Liver Injury, Drug Induced | Hepatitis, Toxic | Toxic Hepatitis | Hepatitides, Toxic | Toxic Hepatitides | Drug-Induced Liver Disease | Disease, Drug-Induced Liver | Diseases, Drug-Induced Liver | Drug Induced Liver Disease | Drug-Induced Liver Diseases | Liver Disease, Drug-Induced | Liver Diseases, Drug-Induced | Drug-Induced Liver Injury | Drug Induced Liver Injury | Drug-Induced Liver Injuries | Injuries, Drug-Induced Liver | Injury, Drug-Induced Liver | Liver Injuries, Drug-Induced | Liver Injury, Drug-Induced | Liver Injury, Drug Induced | Hepatitis, Drug-Induced | Drug-Induced Hepatitides | Drug-Induced Hepatitis | Hepatitides, Drug-Induced | Hepatitis, Drug Induced
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D00648Diazepam--
BADD_D00653Diclofenac0.000376%
BADD_D00680Dimethyl fumarate0.007201%
BADD_D00695Disulfiram0.009442%
BADD_D00706Donepezil0.000282%
BADD_D00718Doxazosin0.000305%
BADD_D00725Doxycycline0.000044%
BADD_D00730Dronedarone0.001078%
BADD_D00734Duloxetine0.000440%
BADD_D00736Dutasteride0.000455%
BADD_D00749Efavirenz0.020186%
BADD_D00766Emtricitabine0.001866%
BADD_D00768Enalaprilat0.010131%
BADD_D00773Entacapone0.002744%
BADD_D00784Epirubicin0.000112%
BADD_D00794Ergocalciferol0.002188%
BADD_D00802Ertapenem0.000049%
BADD_D00804Erythromycin0.000114%
BADD_D00809Escitalopram0.000152%
BADD_D00811Eslicarbazepine--
BADD_D00837Eszopiclone0.000330%
BADD_D00841Ethambutol0.001027%
BADD_D00850Etodolac0.000472%
BADD_D00861Exemestane0.003137%
BADD_D00864Ezetimibe0.000816%
BADD_D00869Famotidine0.000136%
BADD_D00870Febuxostat0.001314%
BADD_D00873Fenofibrate0.001046%
BADD_D00912Fluconazole0.000517%
BADD_D00925Fluocinonide0.000267%
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