Adverse Drug Reaction Classification System

ADR Ontology
ADR Term Drug-induced liver injury
ADR ID BADD_A06676
ADR Hierarchy
09      Hepatobiliary disorders
09.01      Hepatic and hepatobiliary disorders
09.01.07      Hepatocellular damage and hepatitis NEC
09.01.07.023      Drug-induced liver injury
12      Injury, poisoning and procedural complications
12.03      Exposures, chemical injuries and poisoning
12.03.01      Poisoning and toxicity
12.03.01.044      Drug-induced liver injury
Description A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug metabolites, herbal and dietary supplements and chemicals from the environment. | INFLAMMATION of the LIVER due to hepatocellular toxicity, caused by drug metabolites and chemicals from the environment. [MeSH]
MedDRA Code 10072268
MeSH ID D056486
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE) Not Available
Synonym
Drug-induced liver disease | Drug-induced hepatitis | Hepatitis allergic drug-induced | Hepatitis drug-induced | Hepatitis toxic drug-induced | Hy's law case | Drug-induced liver injury | DILI | Drug-induced hepatotoxicity | Herb-induced liver injury | Chemical and Drug Induced Liver Injury | Chemically-Induced Liver Toxicity | Chemically Induced Liver Toxicity | Chemically-Induced Liver Toxicities | Liver Toxicities, Chemically-Induced | Liver Toxicity, Chemically-Induced | Toxicities, Chemically-Induced Liver | Toxicity, Chemically-Induced Liver | Drug-Induced Acute Liver Injury | Drug Induced Acute Liver Injury | Liver Injury, Drug-Induced, Acute | Acute Liver Injury, Drug-Induced | Acute Liver Injury, Drug Induced | Hepatitis, Toxic | Toxic Hepatitis | Hepatitides, Toxic | Toxic Hepatitides | Drug-Induced Liver Disease | Disease, Drug-Induced Liver | Diseases, Drug-Induced Liver | Drug Induced Liver Disease | Drug-Induced Liver Diseases | Liver Disease, Drug-Induced | Liver Diseases, Drug-Induced | Drug-Induced Liver Injury | Drug Induced Liver Injury | Drug-Induced Liver Injuries | Injuries, Drug-Induced Liver | Injury, Drug-Induced Liver | Liver Injuries, Drug-Induced | Liver Injury, Drug-Induced | Liver Injury, Drug Induced | Hepatitis, Drug-Induced | Drug-Induced Hepatitides | Drug-Induced Hepatitis | Hepatitides, Drug-Induced | Hepatitis, Drug Induced
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D01272Levocetirizine0.000194%
BADD_D01275Levofloxacin0.001139%
BADD_D01285Levothyroxine0.000042%
BADD_D01295Linezolid0.005763%
BADD_D01300Lisinopril0.000043%
BADD_D01317Loratadine0.000080%
BADD_D01318Lorazepam0.000169%
BADD_D01322Losartan0.000073%
BADD_D01325Lovastatin0.000187%
BADD_D01328Lubiprostone0.000426%
BADD_D01374Meloxicam0.000135%
BADD_D01378Memantine0.000121%
BADD_D01392Mercaptopurine0.005933%
BADD_D01393Meropenem0.000243%
BADD_D01397Mesalamine0.001006%
BADD_D01401Metformin0.000152%
BADD_D01414Methimazole0.001214%
BADD_D01418Methotrexate--
BADD_D01425Methyldopa0.015093%
BADD_D01433Methylprednisolone0.000352%
BADD_D01442Metoclopramide0.000784%
BADD_D01445Metoprolol0.000053%
BADD_D01449Metronidazole0.000197%
BADD_D01461Midodrine0.000648%
BADD_D01470Minocycline0.005903%
BADD_D01476Mirtazapine0.000520%
BADD_D01490Mometasone0.000059%
BADD_D01496Montelukast0.000112%
BADD_D01515Nafcillin0.000170%
BADD_D01533Naproxen0.000019%
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