Adverse Drug Reaction Classification System

         

ADR Ontology
ADR Term White matter lesion
ADR ID BADD_A06691
ADR Hierarchy
17      Nervous system disorders
17.11      Structural brain disorders
17.11.01      Structural brain disorders NEC
17.11.01.009      White matter lesion
24      Vascular disorders
24.04      Arteriosclerosis, stenosis, vascular insufficiency and necrosis
24.04.06      Cerebrovascular and spinal necrosis and vascular insufficiency
24.04.06.027      White matter lesion
Description Non-specific white matter changes in the BRAIN, often seen after age 65. Changes include loss of AXONS; MYELIN pallor, GLIOSIS, loss of ependymal cells, and enlarged perivascular spaces. Leukoaraiosis is a risk factor for DEMENTIA and CEREBROVASCULAR DISORDERS. [MeSH]
MedDRA Code 10072731
MeSH ID D049292
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE) Not Available
Synonym
Leukoaraiosis | White matter hyperintensities | White matter lesion | Cerebral white matter lesion | Age-related ischemic white matter lesion | Age-related ischaemic white matter lesion | White matter degeneration | Leukoaraioses
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D00039Acyclovir0.000143%
BADD_D00259Betaine0.004312%
BADD_D00349Capecitabine0.000112%
BADD_D00364Carboplatin0.000168%
BADD_D00623Dexamethasone0.000145%
BADD_D00680Dimethyl fumarate0.000880%
BADD_D00749Efavirenz0.005505%
BADD_D00858Everolimus0.000153%
BADD_D00912Fluconazole0.000045%
BADD_D00931Fluorouracil--
BADD_D01265Levetiracetam0.000079%
BADD_D01275Levofloxacin0.000042%
BADD_D01449Metronidazole0.000144%
BADD_D01496Montelukast0.000015%
BADD_D01765Phenytoin0.000191%
BADD_D01835Pregabalin0.000052%
BADD_D01954Rivaroxaban0.000063%
BADD_D02150Temozolomide0.000112%
BADD_D02329Valproic acid--
BADD_D02464Fingolimod0.002869%
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