Adverse Drug Reaction Classification System

ADR Ontology
ADR Term Drug reaction with eosinophilia and systemic symptoms
ADR ID BADD_A06727
ADR Hierarchy
10      Immune system disorders
10.01      Allergic conditions
10.01.01      Allergies to foods, food additives, drugs and other chemicals
10.01.01.021      Drug reaction with eosinophilia and systemic symptoms
23      Skin and subcutaneous tissue disorders
23.03      Epidermal and dermal conditions
23.03.05      Dermatitis ascribed to specific agent
23.03.05.005      Drug reaction with eosinophilia and systemic symptoms
12      Injury, poisoning and procedural complications
12.03      Exposures, chemical injuries and poisoning
12.03.01      Poisoning and toxicity
12.03.01.064      Drug reaction with eosinophilia and systemic symptoms
Description Severe drug eruption characterized by high fever, erythematous rash and inflammation of internal organ(s). [MeSH]
MedDRA Code 10073508
MeSH ID D063926
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE) Not Available
Synonym
DDS syndrome | Hypersensitive syndrome | Hypersensitivity syndrome | Dapsone syndrome | DRESS syndrome | Drug rash with eosinophilia and systemic symptoms | Drug-induced hypersensitivity syndrome | Drug reaction with eosinophilia and systemic symptoms | Drug Hypersensitivity Syndrome | Drug Hypersensitivity Syndromes | Hypersensitivity Syndrome, Drug | Hypersensitivity Syndromes, Drug | Syndrome, Drug Hypersensitivity | Syndromes, Drug Hypersensitivity | DRESS Syndrome | DRESS Syndromes | Drug Reaction with Eosinophilia and Systemic Symptoms | Drug Reaction with Eosinophilia and Systemic Symptoms Syndrome
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D00008Abacavir0.028850%
BADD_D00039Acyclovir0.000285%
BADD_D00076Allopurinol--
BADD_D00103Amikacin0.000169%
BADD_D00121Amlodipine0.000016%
BADD_D00129Amoxicillin0.000417%
BADD_D00142Anastrozole0.000397%
BADD_D00165Aripiprazole0.000713%
BADD_D00178Atenolol0.000174%
BADD_D00186Atovaquone0.000354%
BADD_D00195Azathioprine0.006423%
BADD_D00203Azithromycin0.000013%
BADD_D00206Aztreonam0.000049%
BADD_D00230Bendamustine0.000280%
BADD_D00235Benzalkonium chloride--
BADD_D00277Bisoprolol0.001099%
BADD_D00347Candesartan cilexetil0.002523%
BADD_D00354Captopril0.000975%
BADD_D00356Carbamazepine0.027190%
BADD_D00376Caspofungin0.000449%
BADD_D00379Cefadroxil0.003345%
BADD_D00382Cefazolin0.000097%
BADD_D00386Cefepime0.000316%
BADD_D00388Cefixime0.001085%
BADD_D00390Cefotaxime0.000389%
BADD_D00398Ceftaroline fosamil0.000049%
BADD_D00399Ceftazidime0.000097%
BADD_D00405Ceftriaxone0.122555%
BADD_D00407Cefuroxime0.001145%
BADD_D00410Celecoxib0.000224%
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