Adverse Drug Reaction Classification System

         

ADR Ontology
ADR Term Sinus node dysfunction
ADR ID BADD_A06787
ADR Hierarchy
02      Cardiac disorders
02.03      Cardiac arrhythmias
02.03.03      Supraventricular arrhythmias
02.03.03.017      Sinus node dysfunction
Description A condition caused by dysfunctions related to the SINOATRIAL NODE including impulse generation (CARDIAC SINUS ARREST) and impulse conduction (SINOATRIAL EXIT BLOCK). It is characterized by persistent BRADYCARDIA, chronic ATRIAL FIBRILLATION, and failure to resume sinus rhythm following CARDIOVERSION. This syndrome can be congenital or acquired, particularly after surgical correction for heart defects. [MeSH]
MedDRA Code 10075889
MeSH ID D012804
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE)
Synonym
Sick sinus syndrome | Sinoatrial node dysfunction | Syndrome sick sinus | Bradycardia-tachycardia syndrome | Bradytachycardia | Binodal disease | Sinus node dysfunction | Ectopic atrial bradycardia | Sick Sinus Syndrome | Syndrome, Sick Sinus | Sick Sinus Node Syndrome | Sinus Node Dysfunction | Dysfunction, Sinus Node | Dysfunctions, Sinus Node | Sinus Node Disease | Sinus Node Diseases
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D00033Acetylsalicylic acid0.000022%
BADD_D00066Alendronic acid0.000154%
BADD_D00115Amiodarone0.000404%
BADD_D00116Amiodarone hydrochloride--
BADD_D00121Amlodipine0.000019%
BADD_D00151Apixaban0.000174%
BADD_D00165Aripiprazole0.000079%
BADD_D00178Atenolol0.000068%
BADD_D00190Atropine sulfate--
BADD_D00277Bisoprolol0.001727%
BADD_D00318Busulfan--
BADD_D00349Capecitabine0.000224%
BADD_D00356Carbamazepine0.000558%
BADD_D00499Clomipramine0.001932%
BADD_D00502Clonidine--
BADD_D00535Crizotinib0.000168%
BADD_D00563Dabigatran0.000489%
BADD_D00589Dasatinib0.000168%
BADD_D00629Dexmedetomidine0.000131%
BADD_D00668Digoxin0.000579%
BADD_D00674Diltiazem0.000061%
BADD_D00701Dofetilide0.000169%
BADD_D00706Donepezil0.000705%
BADD_D00718Doxazosin0.000113%
BADD_D00730Dronedarone0.000490%
BADD_D00879Fentanyl--
BADD_D00979Furosemide0.000014%
BADD_D01008Gefitinib--
BADD_D01083Hydrochlorothiazide0.000010%
BADD_D01119Ibrutinib0.000392%
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