Adverse Drug Reaction Classification System

         

ADR Ontology
ADR Term Large granular lymphocytosis
ADR ID BADD_A07350
ADR Hierarchy
01      Blood and lymphatic system disorders
01.10      Leukaemias
01.10.11      Leukaemias chronic T-cell
01.10.11.001      Large granular lymphocytosis
16      Neoplasms benign, malignant and unspecified (incl cysts and polyps)
16.01      Leukaemias
16.01.11      Leukaemias chronic T-cell
16.01.11.001      Large granular lymphocytosis
Description A spectrum of disorders characterized by clonal expansions of the peripheral blood LYMPHOCYTE populations known as large granular lymphocytes which contain abundant cytoplasm and azurophilic granules. Subtypes develop from either CD3-negative NATURAL KILLER CELLS or CD3-positive T-CELLS. The clinical course of both subtypes can vary from spontaneous regression to progressive, malignant disease. [MeSH]
MedDRA Code 10023791
MeSH ID D054066
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE) Not Available
Synonym
Large granular lymphocytosis | T-cell large granular lymphocytic leukemia | Leukemia, Large Granular Lymphocytic | Aggressive NK Cell Leukemia | Leukemia, Lymphocytic, Large Granular | Large Granular Lymphocyte Leukemia | LGL Leukemia | LGL Leukemias | Leukemias, LGL | Lymphoproliferative Disease of Large Granular Lymphocytes | Leukemia, LGL | Aggressive Natural Killer Cell Leukemia | Lymphoproliferative Disease of Granular Lymphocytes | Leukemia, T-Cell Large Granular Lymphocytic | Leukemia, T Cell Large Granular Lymphocytic | T-LGL Leukemia | Leukemias, T-LGL | T LGL Leukemia | T-LGL Leukemias | T-Cell Large Granular Lymphocyte Leukemia | T Cell Large Granular Lymphocyte Leukemia | T-Cell Large Granular Lymphocytic Leukemia | T Cell Large Granular Lymphocytic Leukemia | Leukemia, T-LGL | Leukemia, T LGL | Large Granular Lymphocytosis | Granular Lymphocytoses, Large | Granular Lymphocytosis, Large | Large Granular Lymphocytoses | Lymphocytoses, Large Granular | Lymphocytosis, Large Granular | Leukemia, Natural Killer Cell Large Granular Lymphocytic | Natural Killer Cell Large Granular Lymphocytic Leukemia | Leukemia, NK-LGL | Leukemia, NK LGL | NK-Cell Large Granular Lymphocytic Leukemia | NK Cell Large Granular Lymphocytic Leukemia | NK-LGL Leukemia | Leukemias, NK-LGL | NK LGL Leukemia | NK-LGL Leukemias
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D00511Clozapine0.001834%
BADD_D00589Dasatinib0.001567%
BADD_D01253Lenalidomide0.000362%
BADD_D01834Prednisone0.000009%
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