Adverse Drug Reaction Classification System

ADR Ontology
ADR Term Moyamoya disease
ADR ID BADD_A07443
ADR Hierarchy
17      Nervous system disorders
17.08      Central nervous system vascular disorders
17.08.02      Central nervous system vascular disorders NEC
17.08.02.023      Moyamoya disease
24      Vascular disorders
24.01      Embolism and thrombosis
24.01.04      Cerebrovascular embolism and thrombosis
24.01.04.016      Moyamoya disease
Description A noninflammatory, progressive occlusion of the intracranial CAROTID ARTERIES and the formation of netlike collateral arteries arising from the CIRCLE OF WILLIS. Cerebral angiogram shows the puff-of-smoke (moyamoya) collaterals at the base of the brain. It is characterized by endothelial HYPERPLASIA and FIBROSIS with thickening of arterial walls. This disease primarily affects children but can also occur in adults. [MeSH]
MedDRA Code 10028047
MeSH ID D009072
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE) Not Available
Synonym
Moyamoya disease | Spontaneous occlusion of the circle of Willis | Moyamoya Disease | Progressive Intracranial Occlusive Arteropathy (Moyamoya) | Moyamoya Syndrome | Moya-Moya Disease | Disease, Moya-Moya | Moya Moya Disease | Cerebrovascular Moyamoya Disease | Moyamoya Disease, Primary | Disease, Primary Moyamoya | Moyamoya Diseases, Primary | Primary Moyamoya Disease | Primary Moyamoya Diseases | Moyamoya Disease, Classic | Classic Moyamoya Disease | Disease, Classic Moyamoya | Moyamoya Disease, Secondary | Secondary Moyamoya Disease
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D00594Deferasirox0.001859%
BADD_D01567Nilotinib0.000224%
BADD_D01799Ponatinib0.000168%
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