Adverse Drug Reaction Classification System

ADR Ontology
ADR Term Periodic limb movement disorder
ADR ID BADD_A08758
ADR Hierarchy
15      Musculoskeletal and connective tissue disorders
15.05      Muscle disorders
15.05.03      Muscle related signs and symptoms NEC
15.05.03.034      Periodic limb movement disorder
17      Nervous system disorders
17.15      Sleep disturbances (incl subtypes)
17.15.04      Sleep disturbances NEC
17.15.04.006      Periodic limb movement disorder
19      Psychiatric disorders
19.02      Sleep disorders and disturbances
19.02.05      Dyssomnias
19.02.05.009      Periodic limb movement disorder
Description Excessive periodic leg movements during sleep that cause micro-arousals and interfere with the maintenance of sleep. This condition induces a state of relative sleep deprivation which manifests as excessive daytime hypersomnolence. The movements are characterized by repetitive contractions of the tibialis anterior muscle, extension of the toe, and intermittent flexion of the hip, knee and ankle. (Adams et al., Principles of Neurology, 6th ed, p387) [MeSH]
MedDRA Code 10064600
MeSH ID D020189
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE) Not Available
Synonym
Periodic limb movement disorder (PLMD) | Periodic limb movement disorder | Nocturnal Myoclonus Syndrome | Myoclonus Syndrome, Nocturnal | Nocturnal Myoclonus Syndromes | Syndrome, Nocturnal Myoclonus | Periodic Leg Movements, Excessive, Sleep-Related | Sleep Myoclonus Syndrome | Myoclonus Syndrome, Sleep | Myoclonus Syndromes, Sleep | Sleep Myoclonus Syndromes | Syndrome, Sleep Myoclonus | Syndromes, Sleep Myoclonus | Periodic Movement Disorder, Sleep | Sleep Disorder, Periodic Movements | Sleep-Related Periodic Leg Movements, Excessive | Sleep Related Periodic Leg Movements, Excessive | Excessive Periodic Sleep-Related Leg Movements | Excessive Periodic Sleep Related Leg Movements | Periodic Limb Movement Disorder
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D00066Alendronic acid0.000044%
BADD_D00932Fluoxetine0.000020%
BADD_D01476Mirtazapine0.000080%
BADD_D01756Phentermine0.000371%
BADD_D01951Risperidone0.000327%
BADD_D02010Sertraline0.000047%
BADD_D02047Sodium oxybate0.001449%
BADD_D02236Tofacitinib0.001230%
BADD_D02247Topiramate0.000050%
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