Adverse Drug Reaction Classification System

         

ADR Ontology
ADR Term Tethered cord syndrome
ADR ID BADD_A08845
ADR Hierarchy
17      Nervous system disorders
17.10      Spinal cord and nerve root disorders
17.10.01      Spinal cord and nerve root disorders NEC
17.10.01.023      Tethered cord syndrome
20      Renal and urinary disorders
20.03      Bladder and bladder neck disorders (excl calculi)
20.03.03      Myoneurogenic bladder disorders
20.03.03.007      Tethered cord syndrome
Description Congenital malformations of the central nervous system and adjacent structures related to defective neural tube closure during the first trimester of pregnancy generally occurring between days 18-29 of gestation. Ectodermal and mesodermal malformations (mainly involving the skull and vertebrae) may occur as a result of defects of neural tube closure. (From Joynt, Clinical Neurology, 1992, Ch55, pp31-41) [MeSH]
MedDRA Code 10066334
MeSH ID D009436
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE) Not Available
Synonym
Tethered cord syndrome | Neural Tube Defects | Defect, Neural Tube | Defects, Neural Tube | Neural Tube Defect | Developmental Neural Tube Defects | Neural Tube Developmental Defects | Developmental Defects, Neural Tube | Craniorachischisis | Craniorachischises | Diastematomyelia | Diastematomyelias | Tethered Cord Syndrome | Tethered Cord Syndromes | Occult Spinal Dysraphism Sequence | Tethered Spinal Cord Syndrome | Occult Spinal Dysraphism | Dysraphism, Occult Spinal | Dysraphisms, Occult Spinal | Occult Spinal Dysraphisms | Spinal Dysraphism, Occult | Spinal Dysraphisms, Occult | Iniencephaly | Iniencephalies | Neurenteric Cyst | Cyst, Neurenteric | Cysts, Neurenteric | Neurenteric Cysts | Neuroenteric Cyst | Cyst, Neuroenteric | Cysts, Neuroenteric | Neuroenteric Cysts | Spinal Cord Myelodysplasia | Myelodysplasia, Spinal Cord | Myelodysplasias, Spinal Cord | Spinal Cord Myelodysplasias | Acrania | Acranias | Exencephaly | Exencephalies
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D00209Baclofen0.000104%
BADD_D00932Fluoxetine0.000030%
BADD_D01243Lamotrigine0.000083%
BADD_D01599Olanzapine0.000421%
BADD_D01679Paroxetine0.000171%
BADD_D02010Sertraline0.000019%
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