Adverse Drug Reaction Classification System

         

ADR Ontology
ADR Term Autonomic dysreflexia
ADR ID BADD_A08960
ADR Hierarchy
12      Injury, poisoning and procedural complications
12.01      Injuries NEC
12.01.13      Spinal cord injuries NEC
12.01.13.007      Autonomic dysreflexia
17      Nervous system disorders
17.05      Neuromuscular disorders
17.05.01      Autonomic nervous system disorders
17.05.01.022      Autonomic dysreflexia
24      Vascular disorders
24.08      Vascular hypertensive disorders
24.08.02      Vascular hypertensive disorders NEC
24.08.02.016      Autonomic dysreflexia
Description A syndrome associated with damage to the spinal cord above the mid thoracic level (see SPINAL CORD INJURIES) characterized by a marked increase in the sympathetic response to minor stimuli such as bladder or rectal distention. Manifestations include HYPERTENSION; TACHYCARDIA (or reflex bradycardia); FEVER; FLUSHING; and HYPERHIDROSIS. Extreme hypertension may be associated with a STROKE. (From Adams et al., Principles of Neurology, 6th ed, pp538 and 1232; J Spinal Cord Med 1997;20(3):355-60) [MeSH]
MedDRA Code 10068196
MeSH ID D020211
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE) Not Available
Synonym
Autonomic dysreflexia | Autonomic Dysreflexia | Autonomic Dysreflexias | Dysreflexias, Autonomic | Hyperreflexia, Autonomic | Spinal Autonomic Dysreflexia | Autonomic Dysreflexia, Spinal | Autonomic Dysreflexias, Spinal | Dysreflexia, Spinal Autonomic | Dysreflexias, Spinal Autonomic | Spinal Autonomic Dysreflexias | Autonomic Hyperreflexia | Autonomic Hyperreflexias | Hyperreflexias, Autonomic | Dysreflexia, Autonomic
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D00209Baclofen0.000279%
BADD_D01566Nifedipine0.000075%
BADD_D02098Sumatriptan0.000056%
BADD_D02490Apalutamide0.000501%
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