Adverse Drug Reaction Classification System

ADR Ontology
ADR Term End stage renal disease
ADR ID BADD_A09360
ADR Hierarchy
20      Renal and urinary disorders
20.01      Renal disorders (excl nephropathies)
20.01.03      Renal failure and impairment
20.01.03.019      End stage renal disease
Description The end-stage of CHRONIC RENAL INSUFFICIENCY. It is characterized by the severe irreversible kidney damage (as measured by the level of PROTEINURIA) and the reduction in GLOMERULAR FILTRATION RATE to less than 15 ml per min (Kidney Foundation: Kidney Disease Outcome Quality Initiative, 2002). These patients generally require HEMODIALYSIS or KIDNEY TRANSPLANTATION. [MeSH]
MedDRA Code 10077512
MeSH ID D007676
ADR Severity Grade (FAERS) Not Available
ADR Severity Grade (CTCAE) Not Available
Synonym
End stage renal disease (ESRD) | End stage renal failure | Terminal renal insufficiency | Chronic kidney disease stage 5 | End stage renal disease | Kidney Failure, Chronic | End-Stage Kidney Disease | Disease, End-Stage Kidney | End Stage Kidney Disease | Kidney Disease, End-Stage | Chronic Kidney Failure | End-Stage Renal Disease | Disease, End-Stage Renal | End Stage Renal Disease | Renal Disease, End-Stage | Renal Disease, End Stage | Renal Failure, End-Stage | End-Stage Renal Failure | Renal Failure, End Stage | Renal Failure, Chronic | Chronic Renal Failure | ESRD
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D01304Lithium cation0.001824%
BADD_D01318Lorazepam0.000031%
BADD_D01322Losartan0.000030%
BADD_D01336Macitentan0.000686%
BADD_D01602Olmesartan0.000210%
BADD_D01614Omeprazole0.000108%
BADD_D01668Pantoprazole0.000172%
BADD_D01687Pazopanib0.000112%
BADD_D01783Pirfenidone0.000241%
BADD_D01798Pomalidomide0.001206%
BADD_D01834Prednisone0.000085%
BADD_D01895Quinine0.002936%
BADD_D01898Rabeprazole0.000260%
BADD_D01909Ramipril0.000373%
BADD_D01938Rifaximin0.000322%
BADD_D01951Risperidone0.000364%
BADD_D01978Ruxolitinib0.000206%
BADD_D02006Selexipag0.000082%
BADD_D02028Sirolimus0.000201%
BADD_D02053Sofosbuvir0.000423%
BADD_D02058Sorafenib0.000168%
BADD_D02105Tacrolimus0.005792%
BADD_D02154Tenofovir0.040713%
BADD_D02246Tolvaptan0.000465%
BADD_D02268Treprostinil0.000164%
BADD_D02434Cinacalcet0.000782%
BADD_D02510Rucaparib0.000112%
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