Adverse Drug Reaction Classification System

ADR Ontology
ADR Term Atypical haemolytic uraemic syndrome
ADR ID BADD_A09510
ADR Hierarchy
01      Blood and lymphatic system disorders
01.06      Haemolyses and related conditions
01.06.02      Anaemias haemolytic mechanical factor
01.06.02.003      Atypical haemolytic uraemic syndrome
07      Gastrointestinal disorders
07.11      Gastrointestinal conditions NEC
07.11.01      Gastrointestinal disorders NEC
07.11.01.032      Atypical haemolytic uraemic syndrome
17      Nervous system disorders
17.02      Neurological disorders NEC
17.02.10      Nervous system disorders NEC
17.02.10.027      Atypical haemolytic uraemic syndrome
20      Renal and urinary disorders
20.01      Renal disorders (excl nephropathies)
20.01.03      Renal failure and impairment
20.01.03.027      Atypical haemolytic uraemic syndrome
Description An hereditary hemolytic uremic syndrome associated with variations in the gene that encodes COMPLEMENT FACTOR H, or the related proteins CFHR1 and CFHR3. Disease often progresses to CHRONIC KIDNEY FAILURE without the prodromal symptoms of ENTEROCOLITIS and DIARRHEA that characterize typical hemolytic uremic syndrome. [MeSH]
MedDRA Code 10079840
MeSH ID D065766
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE) Not Available
Synonym
Atypical haemolytic uraemic syndrome | Atypical hemolytic uremic syndrome | aHUS | Atypical Hemolytic Uremic Syndrome | Non-Stx-Hus | Non Stx Hus | Non-Shiga-Like Toxin-Associated HUS | HUS, Non-Shiga-Like Toxin-Associated | HUSs, Non-Shiga-Like Toxin-Associated | Non Shiga Like Toxin Associated HUS | Non-Shiga-Like Toxin-Associated HUSs | Toxin-Associated HUS, Non-Shiga-Like | Toxin-Associated HUSs, Non-Shiga-Like | Hemolytic Uremic Syndrome, Atypical | Nonenteropathic HUS | HUS, Nonenteropathic | HUSs, Nonenteropathic | Nonenteropathic HUSs | Atypical Hemolytic-Uremic Syndrome | Atypical Hemolytic-Uremic Syndromes | Hemolytic-Uremic Syndrome, Atypical | Hemolytic-Uremic Syndromes, Atypical | Syndrome, Atypical Hemolytic-Uremic | Syndromes, Atypical Hemolytic-Uremic
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D00347Candesartan cilexetil0.000841%
BADD_D00367Carfilzomib0.000336%
BADD_D00474Cisplatin0.000168%
BADD_D00821Estradiol0.000031%
BADD_D01231Ketoprofen0.004481%
BADD_D01414Methimazole0.000202%
BADD_D02105Tacrolimus0.001485%
BADD_D02373Warfarin0.000028%
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