Adverse Drug Reaction Classification System

ADR Ontology
ADR Term Carcinoid heart disease
ADR ID BADD_A09595
ADR Hierarchy
02      Cardiac disorders
02.07      Cardiac valve disorders
02.07.02      Cardiac valve disorders NEC
02.07.02.009      Carcinoid heart disease
05      Endocrine disorders
05.08      Neoplastic and ectopic endocrinopathies
05.08.02      Ectopic endocrine disorders
05.08.02.006      Carcinoid heart disease
16      Neoplasms benign, malignant and unspecified (incl cysts and polyps)
16.32      Neoplasm related morbidities
16.32.02      Ectopic hormone secretion syndromes associated with neoplasias
16.32.02.005      Carcinoid heart disease
Description Cardiac manifestation of gastrointestinal CARCINOID TUMOR that metastasizes to the liver. Substances secreted by the tumor cells, including SEROTONIN, promote fibrous plaque formation in ENDOCARDIUM and its underlying layers. These deposits cause distortion of the TRICUSPID VALVE and the PULMONARY VALVE eventually leading to STENOSIS and valve regurgitation. [MeSH]
MedDRA Code 10069010
MeSH ID D002275
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE) Not Available
Synonym
Carcinoid heart disease | Hedinger syndrome | Carcinoid Heart Disease | Carcinoid Heart Diseases | Heart Disease, Carcinoid | Heart Diseases, Carcinoid
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D00858Everolimus0.000306%
BADD_D02412Octreotide0.000186%
BADD_D02568Lutetium oxodotreotide lu-177-
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