Adverse Drug Reaction Classification System

         

ADR Ontology
ADR Term Haemophagocytic lymphohistiocytosis
ADR ID BADD_A10004
ADR Hierarchy
01      Blood and lymphatic system disorders
01.05      Haematological disorders NEC
01.05.01      Haematological disorders
01.05.01.026      Haemophagocytic lymphohistiocytosis
10      Immune system disorders
10.02      Immune disorders NEC
10.02.01      Immune and associated conditions NEC
10.02.01.077      Haemophagocytic lymphohistiocytosis
16      Neoplasms benign, malignant and unspecified (incl cysts and polyps)
16.32      Neoplasm related morbidities
16.32.03      Oncologic complications and emergencies
16.32.03.038      Haemophagocytic lymphohistiocytosis
Description A serious complication of childhood systemic inflammatory disorders that is thought to be caused by excessive activation and proliferation of T-LYMPHOCYTES and MACROPHAGES. It is seen predominantly in children with systemic onset JUVENILE IDIOPATHIC ARTHRITIS. [MeSH]
MedDRA Code 10071583
MeSH ID D055501; D051359
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE) Not Available
Synonym
Histiocytosis haematophagic | Lymphohistiocytosis | Haemophagocytosis | Macrophage activation syndrome | Reactive haemophagocytic syndrome | Reactive hemophagocytic syndrome | Haemophagocytic syndrome | Hemophagocytic syndrome | Hemophagocytosis | Histiocytosis hematophagic | Hemophagocytic lymphohistiocytosis | Haemophagocytic lymphohistiocytosis | Secondary histiocytosis haematophagic | Secondary histiocytosis hematophagic | Secondary haemophagocytic lymphohistiocytosis | Secondary hemophagocytic lymphohistiocytosis | Macrophage Activation Syndrome | Syndrome, Macrophage Activation
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D00103Amikacin0.000127%
BADD_D00129Amoxicillin0.000010%
BADD_D00132Amphotericin b0.000094%
BADD_D00194Azacitidine0.000392%
BADD_D00195Azathioprine0.007519%
BADD_D00230Bendamustine0.000168%
BADD_D00282Blinatumomab--
BADD_D00284Bortezomib0.000168%
BADD_D00318Busulfan0.000280%
BADD_D00356Carbamazepine0.000558%
BADD_D00390Cefotaxime0.000049%
BADD_D00407Cefuroxime0.000143%
BADD_D00551Cyclosporine0.000553%
BADD_D00560Cytarabine0.000392%
BADD_D00589Dasatinib0.000168%
BADD_D00623Dexamethasone0.000654%
BADD_D00766Emtricitabine0.002800%
BADD_D00838Etanercept--
BADD_D00850Etodolac0.000472%
BADD_D00854Etoposide0.000280%
BADD_D00899Fingolimod hydrochloride--
BADD_D00912Fluconazole0.000067%
BADD_D00914Fludarabine0.000839%
BADD_D00931Fluorouracil0.000184%
BADD_D00932Fluoxetine0.000020%
BADD_D01103Hydroxychloroquine0.001859%
BADD_D01119Ibrutinib0.001119%
BADD_D01120Ibuprofen0.000009%
BADD_D01243Lamotrigine0.002980%
BADD_D01252Leflunomide0.000428%
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