Adverse Drug Reaction Classification System

         

ADR Ontology
ADR Term Histiocytic sarcoma
ADR ID BADD_A10042
ADR Hierarchy
01      Blood and lymphatic system disorders
01.13      Haematopoietic neoplasms (excl leukaemias and lymphomas)
01.13.04      Histiocytoses
01.13.04.004      Histiocytic sarcoma
16      Neoplasms benign, malignant and unspecified (incl cysts and polyps)
16.21      Haematopoietic neoplasms (excl leukaemias and lymphomas)
16.21.04      Histiocytoses
16.21.04.004      Histiocytic sarcoma
Description Malignant neoplasms composed of MACROPHAGES or DENDRITIC CELLS. Most histiocytic sarcomas present as localized tumor masses without a leukemic phase. Though the biological behavior of these neoplasms resemble lymphomas, their cell lineage is histiocytic not lymphoid. | A rare, usually progressive disorder comprising an invasive proliferation of neoplastic HISTIOCYTES. Many previous cases are now thought to represent ANAPLASTIC LARGE-CELL LYMPHOMA. [MeSH]
MedDRA Code 10076876
MeSH ID D054747
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE) Not Available
Synonym
Histiocytic sarcoma | Histiocytic Sarcoma | Histiocytic Sarcomas | Sarcoma, Histiocytic | Sarcomas, Histiocytic | True Malignant Histiocytosis | Histiocytoses, True Malignant | Histiocytosis, True Malignant | Malignant Histiocytoses, True | Malignant Histiocytosis, True | True Malignant Histiocytoses | True Histiocytic Lymphoma | Histiocytic Lymphoma, True | Histiocytic Lymphomas, True | Lymphoma, True Histiocytic | Lymphomas, True Histiocytic | True Histiocytic Lymphomas | Histiocytosis, Malignant | Histiocytoses, Malignant | Malignant Histiocytoses | Malignant Histiocytosis
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D01136Imatinib0.000224%
BADD_D02257Trametinib0.000168%
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