Adverse Drug Reaction Classification System

ADR Ontology
ADR Term Malignant catatonia
ADR ID BADD_A10339
ADR Hierarchy
19      Psychiatric disorders
19.11      Changes in physical activity
19.11.01      Decreased physical activity levels
19.11.01.003      Malignant catatonia
Description A neuropsychiatric disorder characterized by one or more of the following essential features: immobility, mutism, negativism (active or passive refusal to follow commands), mannerisms, stereotypies, posturing, grimacing, excitement, echolalia, echopraxia, muscular rigidity, and stupor; sometimes punctuated by sudden violent outbursts, panic, or hallucinations. This condition may be associated with psychiatric illnesses (e.g., SCHIZOPHRENIA; MOOD DISORDERS) or organic disorders (NEUROLEPTIC MALIGNANT SYNDROME; ENCEPHALITIS, etc.). (From DSM-IV, 4th ed, 1994; APA, Thesaurus of Psychological Index Terms, 1994) [MeSH]
MedDRA Code 10080149
MeSH ID D002389
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE) Not Available
Synonym
Malignant catatonia | Catatonia | Catatonias | Catatonia, Organic | Catatonias, Organic | Organic Catatonia | Organic Catatonias | Organic Catatonic Disorder | Catatonic Disorder, Organic | Catatonic Disorders, Organic | Organic Catatonic Disorders | Schizophreniform Catatonia | Catatonia, Schizophreniform | Catatonias, Schizophreniform | Schizophreniform Catatonias | Catatonia, Malignant | Catatonias, Malignant | Malignant Catatonia | Malignant Catatonias | Lethal Catatonia | Catatonia, Lethal | Catatonias, Lethal | Lethal Catatonias
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D00209Baclofen0.000174%
BADD_D00511Clozapine0.005503%
BADD_D01405Methadone0.000398%
BADD_D01599Olanzapine0.000526%
BADD_D01656Paliperidone0.001366%
BADD_D01951Risperidone0.000242%
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