Adverse Drug Reaction Classification System

ADR Ontology
ADR Term Neurofibrosarcoma
ADR ID BADD_A10511
ADR Hierarchy
15      Musculoskeletal and connective tissue disorders
15.09      Musculoskeletal and connective tissue neoplasms
15.09.03      Malignant musculoskeletal and connective tissue neoplasms
15.09.03.033      Neurofibrosarcoma
16      Neoplasms benign, malignant and unspecified (incl cysts and polyps)
16.33      Soft tissue neoplasms malignant and unspecified
16.33.11      Neurofibrosarcomas
16.33.11.001      Neurofibrosarcoma
Description A malignant tumor that arises from small cutaneous nerves, is locally aggressive, and has a potential for metastasis. Characteristic histopathologic features include proliferating atypical spindle cells with slender wavy and pointed nuclei, hypocellular areas, and areas featuring organized whorls of fibroblastic proliferation. The most common primary sites are the extremities, retroperitoneum, and trunk. These tumors tend to present in childhood, often in association with NEUROFIBROMATOSIS 1. (From DeVita et al., Cancer: Principles & Practice of Oncology, 5th ed, p1662; Mayo Clin Proc 1990 Feb;65(2):164-72) | A malignant neurilemmoma with nerve sheath differentiation. It is often associated with NEUROFIBROMATOSIS 1 and RHABDOMYOSARCOMA. [MeSH]
MedDRA Code 10061527
MeSH ID D018319
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE) Not Available
Synonym
Malignant peripheral nerve sheath tumor | Neurilemmoma malignant | Neurilemoma malignant | Neurofibrosarcoma non-metastatic | Neurofibrosarcoma NOS | Neurofibrosarcoma stage unspecified | Peripheral nerve sheath tumor malignant | Peripheral nerve sheath tumour malignant | Schwannoma malignant | Neurofibrosarcoma | Malignant peripheral nerve sheath tumour | Neurosarcoma | Neurofibrosarcomas | Sarcoma, Neurogenic | Neurogenic Sarcoma | Neurogenic Sarcomas | Sarcomas, Neurogenic | Malignant Peripheral Nerve Sheath Tumors | Neurilemmosarcoma | Neurilemmosarcomas | MPNST | Malignant Neurilemmoma | Malignant Neurilemmomas | Neurilemmoma, Malignant | Peripheral Nerve Sheath Tumors, Malignant | Malignant Neurilemoma | Malignant Neurilemomas | Neurilemoma, Malignant | Schwannoma, Malignant | Malignant Schwannoma | Malignant Schwannomas | Malignant Peripheral Nerve Sheath Tumor
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D02257Trametinib0.000112%
BADD_D02493Selinexor0.000951%
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