Adverse Drug Reaction Classification System

ADR Ontology
ADR Term Primary adrenal insufficiency
ADR ID BADD_A10755
ADR Hierarchy
05      Endocrine disorders
05.01      Adrenal gland disorders
05.01.02      Adrenal cortical hypofunctions
05.01.02.012      Primary adrenal insufficiency
14      Metabolism and nutrition disorders
14.11      Metabolism disorders NEC
14.11.01      Metabolic disorders NEC
14.11.01.056      Primary adrenal insufficiency
Description An adrenal disease characterized by the progressive destruction of the ADRENAL CORTEX, resulting in insufficient production of ALDOSTERONE and HYDROCORTISONE. Clinical symptoms include ANOREXIA; NAUSEA; WEIGHT LOSS; MUSCLE WEAKNESS; and HYPERPIGMENTATION of the SKIN due to increase in circulating levels of ACTH precursor hormone which stimulates MELANOCYTES. [MeSH]
MedDRA Code 10052381
MeSH ID D000224
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE) Not Available
Synonym
Primary hypoadrenalism | Primary adrenal insufficiency | Primary adrenocortical insufficiency | Addison Disease | Disease, Addison | Primary Adrenal Insufficiency | Adrenal Insufficiency, Primary | Primary Hypoadrenalism | Hypoadrenalism, Primary | Hypoadrenalisms, Primary | Addison's Disease | Addisons Disease | Primary Adrenocortical Insufficiency | Adrenocortical Insufficiencies, Primary | Adrenocortical Insufficiency, Primary | Insufficiencies, Primary Adrenocortical | Insufficiency, Primary Adrenocortical | Primary Adrenocortical Insufficiencies
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D01254Lenvatinib0.000504%
BADD_D01285Levothyroxine0.000007%
BADD_D01804Posaconazole0.004728%
BADD_D01831Prednisolone0.000052%
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