Adverse Drug Reaction Classification System

         

ADR Ontology
ADR Term Primary amyloidosis
ADR ID BADD_A10756
ADR Hierarchy
10      Immune system disorders
10.02      Immune disorders NEC
10.02.05      Amyloidoses
10.02.05.009      Primary amyloidosis
Description A nonproliferative disorder of the PLASMA CELL characterized by excessive production and misfolding of IMMUNOGLOBULIN LIGHT CHAINS that form insoluble amyloid fibrils (see AMYLOID DEPOSITS) in various tissues. Clinical features include LIVER FAILURE; MULTIPLE MYELOMA; NEPHROTIC SYNDROME; RESTRICTIVE CARDIOMYOPATHY, and neuropathies. [MeSH]
MedDRA Code 10036673
MeSH ID D000075363
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE) Not Available
Synonym
Primary amyloidosis | Amyloid light-chain amyloidosis | AL amyloidosis | Immunoglobulin Light-chain Amyloidosis | Immunoglobulin Light chain Amyloidosis | Immunoglobulin Light-chain Amyloidoses | Amyloidosis, Primary | AL Amyloidosis | AL Amyloidoses | Primary Systemic Amyloidosis | Amyloidoses, Primary Systemic | Amyloidosis, Primary Systemic | Primary Systemic Amyloidoses | Systemic Amyloidoses, Primary | Systemic Amyloidosis, Primary | Amyloidosis, Immunoglobulin Light-chain | Amyloidosis, Immunoglobulin Light chain | Primary Amyloidosis | Amyloidoses, Primary | Primary Amyloidoses
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D00284Bortezomib0.000392%
BADD_D01217Itraconazole--
BADD_D01253Lenalidomide0.000241%
BADD_D02373Warfarin0.000028%
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