| Pharmaceutical Information |
| Drug Name |
Abacavir |
| Drug ID |
BADD_D00008 |
| Description |
Abacavir (ABC) is a powerful nucleoside analog reverse transcriptase inhibitor (NRTI) used to treat HIV and AIDS. Chemically, it is a synthetic carbocyclic nucleoside and is the enantiomer with 1S, 4R absolute configuration on the cyclopentene ring. In vivo, abacavir sulfate dissociates to its free base, abacavir. |
| Indications and Usage |
For the treatment of HIV-1 infection, in combination with other antiretroviral agents. |
| Marketing Status |
approved; investigational |
| ATC Code |
J05AF06 |
| DrugBank ID |
DB01048
|
| KEGG ID |
D07057
|
| MeSH ID |
C106538
|
| PubChem ID |
441300
|
| TTD Drug ID |
D0A4IJ
|
| NDC Product Code |
55111-920; 72865-167; 50268-049; 31722-562; 70518-1274; 65862-073; 31722-557; 68084-021; 0904-6874; 64380-717; 69097-514 |
| UNII |
WR2TIP26VS
|
| Synonyms |
abacavir | 1592U89 | abacavir sulfate | Ziagen | (1S,4R)-4-(2-amino-6-(cyclopropylamino)-9H-purin-9-yl)-2-cyclopentene-1-methanol | abacavir succinate |
|
| Chemical Information |
| Molecular Formula |
C14H18N6O |
| CAS Registry Number |
136470-78-5 |
| SMILES |
C1CC1NC2=C3C(=NC(=N2)N)N(C=N3)C4CC(C=C4)CO |
| Chemical Structure |
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| ADRs Induced by Drug |
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*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
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| ADR Term |
ADReCS ID |
ADR Frequency (FAERS)
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ADR Severity Grade (FAERS)
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ADR Severity Grade (CTCAE)
|
| Therapy non-responder | 08.06.01.063 | 0.004121% | | Not Available | | Treatment noncompliance | 12.09.02.006; 08.06.01.067 | 0.004121% | | Not Available |
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