| Pharmaceutical Information |
| Drug Name |
Abciximab |
| Drug ID |
BADD_D00013 |
| Description |
Abciximab is a Fab fragment of the chimeric human-murine monoclonal antibody 7E3. Abciximab binds to the glycoprotein (GP) IIb/IIIa receptor of human platelets and inhibits platelet aggregation by preventing the binding of fibrinogen, von Willebrand factor, and other adhesive molecules. It also binds to vitronectin (αvβ3) receptor found on platelets and vessel wall endothelial and smooth muscle cells. |
| Indications and Usage |
Abciximab is indicated as an adjunct to percutaneous coronary intervention for the prevention of cardiac ischemic complications in patients undergoing percutaneous coronary intervention and in patients with unstable angina not responding to conventional medical therapy when percutaneous coronary intervention is planned within 24 hours. Abciximab is intended for use with aspirin and heparin and has been studied only in that setting. |
| Marketing Status |
approved |
| ATC Code |
B01AC13 |
| DrugBank ID |
DB00054
|
| KEGG ID |
D02778
|
| MeSH ID |
D000077284
|
| PubChem ID |
Not Available
|
| TTD Drug ID |
D0P3TX
|
| NDC Product Code |
Not Available |
| UNII |
X85G7936GV
|
| Synonyms |
Abciximab | c7E3 Fab | Chimeric 7E3 Fab | Fab, Chimeric 7E3 | ReoPro | Clotinab | CentoRx |
|
| Chemical Information |
| Molecular Formula |
Not Available |
| CAS Registry Number |
143653-53-6 |
| SMILES |
Not Available |
| Chemical Structure |
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| ADRs Induced by Drug |
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*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
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