Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Abiraterone
Drug ID BADD_D00014
Description Abiraterone is a derivative of steroidal progesterone and is an innovative drug that offers clinical benefit to patients with hormone refractory prostate cancer. Abiraterone is administered as an acetate salt prodrug because it has a higher bioavailability and less susceptible to hydrolysis than abiraterone itself. FDA approved on April 28, 2011.
Indications and Usage Used in combination with prednisone for the treatment of metastatic, castration-resistant prostate cancer.
Marketing Status approved
ATC Code L02BX03
DrugBank ID DB05812
KEGG ID Not Available
MeSH ID C089740
PubChem ID 132971
TTD Drug ID D02STN
NDC Product Code 42291-024; 42291-073; 69238-1754; 60219-1754; 60687-455; 17337-0082; 54893-0070; 30007-838; 69238-1165; 60219-1165
UNII G819A456D0
Synonyms abiraterone | 17-(3-pyridyl)androsta-5,16-dien-3beta-ol | CB-7598 | CB 7598 | CB7598
Chemical Information
Molecular Formula C24H31NO
CAS Registry Number 154229-19-3
SMILES CC12CCC(CC1=CCC3C2CCC4(C3CC=C4C5=CN=CC=C5)C)O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Neoplasm progression16.16.02.005--Not Available
Spinal cord disorder17.10.01.0100.000734%Not Available
Sudden hearing loss04.02.01.0090.000334%Not Available
Decreased appetite14.03.01.005; 08.01.09.0280.031733%
Renal injury20.01.03.015; 12.01.05.0010.000501%Not Available
Intervertebral disc disorder15.10.01.0030.000334%Not Available
Urinary tract obstruction20.08.01.0040.002002%
Blood disorder01.05.01.0040.001468%Not Available
Adverse drug reaction08.06.01.0090.019287%Not Available
Bone lesion15.02.04.0160.001168%Not Available
Disease progression08.01.03.0380.107744%
Gastrointestinal obstruction07.13.01.0050.000334%Not Available
Hepatic lesion09.01.08.0050.000334%Not Available
Metastasis16.22.01.0010.002402%Not Available
Peripheral arterial occlusive disease24.04.03.0100.000334%Not Available
Haemorrhagic diathesis24.07.01.020; 01.01.03.0030.000334%Not Available
Hypophagia19.09.01.004; 14.03.01.006; 07.01.06.0100.003270%Not Available
Gastrointestinal inflammation07.08.03.0070.001135%Not Available
Skin haemorrhage24.07.01.103; 23.06.07.0010.000901%Not Available
Osteonecrosis of jaw24.04.05.005; 15.02.04.0100.002402%
Urethral stenosis20.07.03.0030.000734%Not Available
Penile oedema21.12.01.0070.000501%Not Available
Liver injury12.01.17.012; 09.01.07.0220.001735%Not Available
Adverse reaction08.06.01.0180.002136%Not Available
Head and neck cancer16.16.01.0030.000334%Not Available
Hypertransaminasaemia09.01.02.0050.000667%Not Available
Tumour compression16.32.03.0210.000734%Not Available
Drug-induced liver injury12.03.01.044; 09.01.07.0230.003904%Not Available
Cholangitis acute09.02.01.0060.000334%Not Available
Hyperaldosteronism24.08.04.005; 05.01.01.006; 14.05.04.0060.000334%Not Available
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