Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Abiraterone
Drug ID BADD_D00014
Description Abiraterone is a derivative of steroidal progesterone and is an innovative drug that offers clinical benefit to patients with hormone refractory prostate cancer. Abiraterone is administered as an acetate salt prodrug because it has a higher bioavailability and less susceptible to hydrolysis than abiraterone itself. FDA approved on April 28, 2011.
Indications and Usage Used in combination with prednisone for the treatment of metastatic, castration-resistant prostate cancer.
Marketing Status approved
ATC Code L02BX03
DrugBank ID DB05812
KEGG ID Not Available
MeSH ID C089740
PubChem ID 132971
TTD Drug ID D02STN
NDC Product Code 42291-024; 42291-073; 69238-1754; 60219-1754; 60687-455; 17337-0082; 54893-0070; 30007-838; 69238-1165; 60219-1165
UNII G819A456D0
Synonyms abiraterone | 17-(3-pyridyl)androsta-5,16-dien-3beta-ol | CB-7598 | CB 7598 | CB7598
Chemical Information
Molecular Formula C24H31NO
CAS Registry Number 154229-19-3
SMILES CC12CCC(CC1=CCC3C2CCC4(C3CC=C4C5=CN=CC=C5)C)O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Bone neoplasm16.29.01.001; 15.09.02.001--Not Available
Bone pain15.02.01.0010.010277%
Cachexia16.32.03.011; 14.03.02.001; 08.01.01.0090.000334%Not Available
Cardiac failure02.05.01.0010.010077%
Cardiac failure congestive02.05.01.0020.005706%Not Available
Cardio-respiratory arrest22.02.06.007; 02.03.04.002--Not Available
Cardiovascular disorder02.11.01.010; 24.03.02.0090.001502%Not Available
Cataract06.06.01.001--
Cerebral haemorrhage24.07.04.001; 17.08.01.003--Not Available
Cerebrovascular accident24.03.05.001; 17.08.01.0070.013681%
Chest discomfort08.01.08.019; 02.02.02.009; 22.12.02.002--Not Available
Chest pain22.12.02.003; 08.01.08.002; 02.02.02.011--Not Available
Choking22.12.03.0030.001735%Not Available
Cholangitis09.02.01.0020.000501%Not Available
Cholecystitis acute09.03.01.0030.000334%Not Available
Chromaturia20.02.01.0020.002936%
Colon cancer16.13.01.001; 07.21.01.0010.001835%Not Available
Coma hepatic17.02.09.002; 09.01.03.0050.000334%Not Available
Confusional state19.13.01.001; 17.02.03.005--
Constipation07.02.02.0010.029097%
Coronary artery occlusion24.04.04.013; 02.02.01.006; 12.02.01.0360.000501%Not Available
Cough22.02.03.001--
Cushing's syndrome24.08.04.001; 19.07.03.002; 14.11.01.007; 05.01.01.0010.000834%Not Available
Cushingoid14.11.01.006; 05.01.01.002; 24.08.02.004; 19.07.03.0010.001301%
Death08.04.01.0010.318462%
Decubitus ulcer23.03.11.0060.000334%Not Available
Dehydration14.05.05.0010.011879%
Dementia17.03.01.001; 19.20.02.0010.004238%Not Available
Dermatitis23.03.04.002--Not Available
Diabetes mellitus14.06.01.001; 05.06.01.0010.010377%Not Available
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