ADReCS

Pharmaceutical Information

Drug Name	Acetylcysteine
Drug ID	BADD_D00032
Description	Acetylcysteine is an antioxidant and glutathione inducer indicated for mucolytic therapy and the treatment of [acetaminophen] overdose.[L31378,L31383,L31388,L31478] Acetylcysteine has also been studied for a wide variety of off-label indications with mixed results.[A228158,A228163,A228168] Acetylcysteine was granted FDA approval on 14 September 1963.[L31488]
Indications and Usage	Acetylcysteine is indicated for mucolytic therapy and in the management of [acetaminophen] overdose.[L31378,L31383,L31388,L31478]
Marketing Status	approved; investigational
ATC Code	R05CB01; S01XA08; V03AB23
DrugBank ID	DB06151
KEGG ID	D00221
MeSH ID	D000111
PubChem ID	12035
TTD Drug ID	D06XGW
NDC Product Code	70594-111; 12598-7311; 49452-0098; 51552-0201; 51927-1601; 63323-694; 70710-1015; 55150-259; 66220-207; 0517-7610; 55154-5731; 12598-7302; 12598-7308; 12598-7323; 14445-412; 63323-963; 0409-3307; 0517-7504; 0517-7630; 72611-860; 83270-001; 25021-812; 63323-693; 63323-695; 0409-3308; 0517-7604; 17478-660; 63323-690; 63323-692; 0517-7510; 70771-1412; 52932-0704; 63323-691; 12598-7027; 52951-001; 0574-0805; 12598-7294; 12598-7327; 52133-0002; 52932-0742; 55154-5730
UNII	WYQ7N0BPYC
Synonyms	Acetylcysteine \| N-Acetyl-L-cysteine \| N Acetyl L cysteine \| N-Acetylcysteine \| N Acetylcysteine \| Mercapturic Acid \| Acid, Mercapturic \| Solmucol \| Genac \| Acemuc \| Acetabs \| Acetylcystein AL \| NAC AL \| Acetylcystein Atid \| Acetylcystein Heumann \| Acetylcystein Trom \| Acetylcysteine Hydrochloride \| Hydrochloride, Acetylcysteine \| Acetylcysteine Sodium \| Sodium, Acetylcysteine \| Acetylcysteine, Monosodium Salt \| Monosodium Salt Acetylcysteine \| Acetylcysteine Zinc \| Zinc, Acetylcysteine \| Acetylcysteine, (D)-Isomer \| Acetylcysteine, (DL)-Isomer \| Acetylcysteine, Monoammonium Salt \| Monoammonium Salt Acetylcysteine \| Acetyst \| Acétylcystéine GNR \| Airbron \| Alveolex \| Bromuc \| Azubronchin \| Bisolvon NAC \| NAC, Bisolvon \| Broncho-Fips \| Broncho Fips \| BronchoFips \| Broncholysin \| Broncoclar \| Codotussyl \| Cystamucil \| Dampo Mucopect \| Mucopect, Dampo \| durabronchal \| Larylin NAC \| Eurespiran \| Exomuc \| Fluimucil \| NAC Zambon \| Zambon, NAC \| Fabrol \| Fluprowit \| Optipect Hustengetränk \| Hustengetränk, Optipect \| Muco Sanigen \| Sanigen, Muco \| Frekatuss \| Jenacystein \| Jenapharm \| Lantamed \| Lindocetyl \| M-Pectil \| M Pectil \| MPectil \| mentopin Acetylcystein \| Acetylcystein, mentopin \| Muciteran \| Mucomyst \| Acetylin \| Mucosil \| Mucosol \| Mucosolvin \| Siccoral \| Siran \| Ilube \| Hoestil \| acebraus

Chemical Information

Molecular Formula	C5H9NO3S
CAS Registry Number	616-91-1
SMILES	CC(=O)NC(CS)C(=O)O
Chemical Structure

ADRs Induced by Drug

*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..

ADR Term	ADReCS ID	ADR Frequency (FAERS)	ADR Severity Grade (FAERS)	ADR Severity Grade (CTCAE)
Abdominal pain	07.01.05.002	-	-
Abdominal pain upper	07.01.05.003	0.000223%
Acute hepatic failure	09.01.03.001	0.000223%		Not Available
Agitation	19.06.02.001; 17.02.05.012	0.000446%
Amnesia	19.20.01.001; 17.03.02.001	0.000149%
Anaphylactic reaction	10.01.07.001; 24.06.03.006	0.000922%
Anaphylactic shock	24.06.02.004; 10.01.07.002	0.000774%		Not Available
Anaphylactoid reaction	24.06.03.007; 10.01.07.003	0.001220%		Not Available
Angioedema	22.04.02.008; 23.04.01.001; 10.01.05.009	0.000372%		Not Available
Arthralgia	15.01.02.001	-	-
Asphyxia	22.02.02.001; 12.01.08.011	0.000149%		Not Available
Asthma	22.03.01.002; 10.01.03.010	0.000298%		Not Available
Atrial fibrillation	02.03.03.002	0.000149%
Blister	12.01.06.002; 23.03.01.001	0.000655%		Not Available
Body temperature increased	13.15.01.001	-	-	Not Available
Bronchospasm	10.01.03.012; 22.03.01.004	0.000729%
Chest discomfort	08.01.08.019; 02.02.02.009; 22.12.02.002	0.000476%		Not Available
Chills	15.05.03.016; 08.01.09.001	-	-
Cholestasis	09.01.01.001	0.000223%		Not Available
Coagulopathy	01.01.02.001	0.000372%		Not Available
Cold sweat	23.02.03.002; 08.01.03.024	-	-	Not Available
Compartment syndrome	24.04.05.006; 15.05.05.005	0.000298%		Not Available
Condition aggravated	08.01.03.004	0.000372%		Not Available
Confusional state	19.13.01.001; 17.02.03.005	0.000149%
Cough	22.02.03.001	0.000223%
Cutaneous vasculitis	24.12.04.008; 23.06.02.001; 10.02.02.003	-	-	Not Available
Depressed level of consciousness	17.02.04.002	0.000149%
Dermatitis	23.03.04.002	-	-	Not Available
Diabetes mellitus	14.06.01.001; 05.06.01.001	0.000149%		Not Available
Dizziness	17.02.05.003; 02.11.04.006; 24.06.02.007	0.000372%

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