Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Acitretin
Drug ID BADD_D00036
Description An oral retinoid effective in the treatment of psoriasis. It is the major metabolite of etretinate with the advantage of a much shorter half-life when compared with etretinate.
Indications and Usage For the treatment of severe psoriasis in adults.
Marketing Status approved
ATC Code D05BB02
DrugBank ID DB00459
KEGG ID D02754
MeSH ID D017255
PubChem ID 5284513
TTD Drug ID D05QDC
NDC Product Code 17337-0003; 59981-011; 0093-1136; 0115-1752; 42291-087; 62147-0145; 0115-1751; 42794-081; 0378-7020; 71214-0698; 42291-088; 58159-058; 71052-692; 0115-1753; 17337-0004; 71214-0667; 0115-1750; 71214-0668; 71214-0669; 42291-086; 42794-080; 0093-1135; 0093-1138; 62147-0146; 76055-0001; 42794-083; 0378-7023
UNII LCH760E9T7
Synonyms Acitretin | Etretin | Isoacitretin | Isoetretin | Ro 10-1670 | Ro 101670 | Ro-10-1670 | Ro101670 | 13-cis-Acitretin | Neotigason | Soriatane | Acitretin, (Z,E,E,E)-Isomer | Ro-13-7652 | Ro137652 | Ro 13-7652 | Ro 137652
Chemical Information
Molecular Formula C21H26O3
CAS Registry Number 55079-83-9
SMILES CC1=CC(=C(C(=C1C=CC(=CC=CC(=CC(=O)O)C)C)C)C)OC
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal pain07.01.05.0020.001250%
Acne23.02.01.001--Not Available
Acute hepatic failure09.01.03.0010.001250%Not Available
Acute myocardial infarction24.04.04.001; 02.02.02.001--Not Available
Ageusia17.02.07.001; 07.14.03.003--Not Available
Aggression19.05.01.001--Not Available
Alanine aminotransferase increased13.03.04.005--
Alcohol abuse19.07.06.001--Not Available
Alcohol intolerance14.02.01.001--
Alcoholism19.07.06.006--Not Available
Alopecia23.02.02.0010.004374%
Anaemia01.03.02.0010.001250%
Angioedema23.04.01.001; 10.01.05.009; 22.04.02.008--Not Available
Anorectal disorder07.03.01.001--Not Available
Anxiety19.06.02.002--
Arthralgia15.01.02.0010.005249%
Arthritis15.01.01.001--
Arthropathy15.01.01.0030.001250%Not Available
Aspartate aminotransferase increased13.03.04.011--
Asthenia08.01.01.001--Not Available
Atrophic vulvovaginitis21.02.01.003--Not Available
Back pain15.03.04.005--
Balanoposthitis21.09.03.001--Not Available
Basal cell carcinoma23.08.02.001; 16.03.02.0010.001875%Not Available
Basophil count increased13.01.06.002--Not Available
Bilirubin conjugated increased13.03.04.014--Not Available
Bleeding time prolonged13.01.02.002--Not Available
Blepharitis06.04.04.001; 23.03.04.012--Not Available
Blindness06.02.10.003; 17.17.01.003--Not Available
Blister23.03.01.001; 12.01.06.0020.001250%Not Available
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ADReCS-Target
Drug Name ADR Term Target
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