Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Amantadine
Drug ID BADD_D00097
Description An antiviral that is used in the prophylactic or symptomatic treatment of influenza A. It is also used as an antiparkinsonian agent, to treat extrapyramidal reactions, and for postherpetic neuralgia. The mechanisms of its effects in movement disorders are not well understood but probably reflect an increase in synthesis and release of dopamine, with perhaps some inhibition of dopamine uptake.
Indications and Usage For the chemoprophylaxis, prophylaxis, and treatment of signs and symptoms of infection caused by various strains of influenza A virus. Also for the treatment of parkinsonism and drug-induced extrapyramidal reactions.
Marketing Status approved
ATC Code N04BB01
DrugBank ID DB00915
KEGG ID D07441
MeSH ID D000547
PubChem ID 2130
TTD Drug ID D02KRS
NDC Product Code 11014-0245; 70482-075; 46708-246; 62332-246; 70482-076; 62332-586; 70482-170; 60687-422; 70482-085; 11014-0234; 46708-586
UNII BF4C9Z1J53
Synonyms Amantadine | 1-Aminoadamantane | 1 Aminoadamantane | Adamantylamine | Wiregyt | Amanta | Amanta-HCI-AZU | Amanta HCI AZU | AmantaHCIAZU | Amanta-Sulfate-AZU | Amanta Sulfate AZU | AmantaSulfateAZU | Amantadin AZU | AZU, Amantadin | Amantadin AL | AL, Amantadin | Amantadin Stada | Stada, Amantadin | Amantadin-neuraxpharm | Amantadin neuraxpharm | Amantadinneuraxpharm | Amantadin-ratiopharm | Amantadin ratiopharm | Amantadinratiopharm | Amantadina Juventus | Juventus, Amantadina | Amantadina Llorente | Llorente, Amantadina | Amantadine Hydrochloride | Hydrochloride, Amantadine | Amantadine Sulfate | Sulfate, Amantadine | Amixx | Cerebramed | Gen-Amantadine | Gen Amantadine | GenAmantadine | Infecto-Flu | Infecto Flu | InfectoFlu | Infex | Midantan | PMS-Amantadine | PMS Amantadine | PMSAmantadine | Symadine | Symmetrel | Endantadine | Mantadix | tregor | Viregyt | Adekin | Aman
Chemical Information
Molecular Formula C10H17N
CAS Registry Number 768-94-5
SMILES C1C2CC3CC1CC(C2)(C3)N
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Gait disturbance15.03.05.013; 17.02.05.016; 08.01.02.0020.001926%
Gastrointestinal disorder07.11.01.001--Not Available
Hallucination19.10.04.0030.016156%
Hallucination, visual19.10.04.0070.002123%Not Available
Headache17.14.01.001--
Hyperhidrosis23.02.03.004; 08.01.03.0280.000865%
Hyperkinesia17.01.02.008--Not Available
Hypersensitivity10.01.03.003--
Hypertension24.08.02.001--
Hypertonia17.05.02.001; 15.05.04.007--Not Available
Hypokinesia17.01.02.009--Not Available
Hypotension24.06.03.002--
Hypothermia12.05.03.001; 08.05.01.003--
Insomnia19.02.01.002; 17.15.03.0020.005739%
Irritability19.04.02.013; 08.01.03.011--
Keratitis06.04.02.002--
Lethargy17.02.04.003; 19.04.04.004; 08.01.01.008--
Leukocytosis01.02.01.002--
Leukopenia01.02.02.001--Not Available
Libido decreased21.03.02.005; 19.08.03.001--
Libido increased21.03.02.007; 19.08.03.002--
Livedo reticularis24.03.04.003; 23.06.05.0010.004206%Not Available
Liver function test abnormal13.03.04.030--Not Available
Loss of consciousness17.02.04.0040.000393%Not Available
Mania19.16.02.002--
Memory impairment19.20.01.003; 17.03.02.0030.000865%
Mental disability26.01.01.001--Not Available
Mental impairment19.21.02.003; 17.03.03.002--Not Available
Mood altered19.04.02.0070.000865%Not Available
Movement disorder17.01.02.0100.000865%Not Available
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