Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Aminophylline
Drug ID BADD_D00112
Description Aminophylline is a drug combination that contains theophylline and ethylenediamine in a 2:1 ratio. Once in the body, theophylline is released and acts as a phosphodiesterase inhibitor, adenosine receptor blocker, and histone deacetylase activator. Similar to other theophyllines, aminophylline is indicated for the treatment of lung diseases such as asthma, chronic bronchitis, and COPD. The majority of aminophylline medications are discontinued and the remaining medications on the market are in short supply.
Indications and Usage For the treatment of bronchospasm due to asthma, emphysema and chronic bronchitis.
Marketing Status approved
ATC Code R03DA05
DrugBank ID DB01223
KEGG ID D00227
MeSH ID D000628
PubChem ID 9433
TTD Drug ID D03TYI
NDC Product Code 51662-1204; 0404-9813; 71872-7060; 0409-5922; 0409-5921; 52584-922; 0404-9814; 51662-1341; 52584-921; 73212-047; 71872-7121; 58624-0544
UNII 27Y3KJK423
Synonyms Aminophylline | Theophylline Ethylenediamine | Ethylenediamine, Theophylline | Theophyllamine | Phyllotemp | Mundiphyllin | Theophyllamin Jenapharm | Theophyllin EDA-ratiopharm | Theophyllin EDA ratiopharm | Theophyllin EDAratiopharm | Truphylline | Afonilum | Carine | Eufilina | Euphyllin | Aminodur | Aminophyllin | Aminophylline DF | Cardophyllin | Clonofilin | Corophyllin | Diaphyllin | Drafilyn | Duraphyllin | Eufilina Venosa | Euphyllin Retard | Euphylline | Godafilin | Mini-Lix | Mundiphyllin Retard | Novophyllin | Phyllocontin | Somophyllin | Tari-Dog
Chemical Information
Molecular Formula C16H24N10O4
CAS Registry Number 317-34-0
SMILES CN1C2=C(C(=O)N(C1=O)C)NC=N2.CN1C2=C(C(=O)N(C1=O)C)NC=N2.C(CN)N
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Hyperhidrosis23.02.03.004; 08.01.03.028--
Hypersensitivity10.01.03.003--
Hypokalaemia14.05.03.002--
Hypotension24.06.03.002--
Insomnia19.02.01.002; 17.15.03.002--
Irritability19.04.02.013; 08.01.03.011--
Melaena24.07.02.013; 07.12.02.004--Not Available
Nausea07.01.07.001--
Nervousness19.06.02.003--Not Available
Overdose12.11.01.002--Not Available
Palpitations02.11.04.012--
Polyuria20.02.03.002--Not Available
Pruritus23.03.12.001--
Rash23.03.13.001--Not Available
Rash maculo-papular23.03.13.004--
Rhabdomyolysis15.05.05.002--
Seizure17.12.03.001--
Shock24.06.02.002--Not Available
Sinus tachycardia02.03.03.010--
Skin exfoliation23.03.07.003--Not Available
Skin necrosis23.03.03.011--Not Available
Somnolence19.02.05.003; 17.02.04.006--
Supraventricular tachycardia02.03.03.012--
Tachycardia02.03.02.007--Not Available
Tachypnoea22.02.01.014--Not Available
Tension19.06.02.005--Not Available
Tremor17.01.06.002--
Urticaria23.04.02.001; 10.01.06.001--
Ventricular arrhythmia02.03.04.006--
Ventricular extrasystoles02.03.04.007--Not Available
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ADReCS-Target
Drug Name ADR Term Target
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