Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Amoxicillin
Drug ID BADD_D00129
Description Amoxicillin, or BRL-2333, is a penicillin G derivative first described in the literature in 1972.[A190648] Amoxicillin has similar activity to [penicillin] and [ampicillin], but leads to higher serum concentrations than ampicillin.[A190648] Amoxicillin was granted FDA approval on 18 January 1974.[L11644]
Indications and Usage Amoxicillin alone is indicated to treat susceptible bacterial infections of the ear, nose, throat, genitourinary tract, skin, skin structure, and lower respiratory tract.[L11656,L11659] Amoxicillin is given with calvulanic acid to treat acute bacterial sinusitis, community acquired pneumonia, lower respiratory tract infections, acute bacterial otitis media, skin and skin structure infections, and urinary tract infections.[L11650,L7880,L11653] Amoxicillin is given with omeprazole in the treatment of _H. pylori_.[L9743,L11647]
Marketing Status approved; vet_approved
ATC Code J01CA04
DrugBank ID DB01060
KEGG ID D00229; D07452
MeSH ID D000658
PubChem ID 33613
TTD Drug ID D0F6EO
NDC Product Code 0781-5060; 55657-101; 55657-106; 59651-099; 65862-274; 0093-2268; 0093-4161; 43063-563; 0143-9886; 50090-0304; 50090-0858; 50090-1511; 50090-5863; 50090-5880; 51655-156; 53002-0130; 53002-2080; 55289-182; 57237-029; 61919-672; 61919-716; 63187-200; 63187-591; 68071-1760; 68071-2908; 68071-4548; 68788-8240; 70518-0895; 72789-224; 76420-192; 81964-225; 43063-820; 50090-0713; 50090-6056; 50090-6466; 53002-1369; 55289-019; 57237-028; 61919-401; 63187-044; 63187-295; 65862-071; 65862-706; 67296-1156; 68071-4455; 68788-7318; 68788-9948; 70518-2188; 70518-2190; 70518-3294; 71205-177; 71205-436; 76420-112; 76420-508; 0781-6039; 0093-4160; 0143-9285; 43063-341; 63187-262; 63629-7587; 63629-7798; 63629-7801; 68071-2766; 68071-2875; 68071-3119; 68788-6374; 68999-825; 55289-020; 63187-043; 63187-186; 63629-7633; 66267-994; 67296-1894; 68071-4693; 68071-4741; 68788-8324; 71205-035; 71205-422; 0781-6041; 16714-299; 0093-2267; 42571-234; 42708-153; 43063-574; 50090-0288; 50090-1512; 50090-1812; 50090-6351; 53002-2369; 63187-027; 67296-0986; 68071-2558; 68788-8209; 68788-8304; 68788-8325; 68788-9018; 71205-507; 76420-003; 52115-001; 65862-014; 65862-017; 50090-0406; 50090-0407; 50090-6469; 53002-2160; 57237-032; 63187-325; 68071-4953; 70518-2191; 70882-113; 70934-038; 76420-545; 16714-298; 0093-2264; 42708-010; 42708-076; 0143-9888; 0143-9939; 50090-1810; 53002-2090; 63187-029; 63187-399; 63187-880; 65862-707; 68071-2604; 70518-3234; 70882-114; 71205-266; 72789-254; 0781-2613; 0781-5061; 0781-6156; 42708-112; 43063-885; 50090-0301; 50090-0404; 50090-1086; 50090-1347; 61919-135; 63187-013; 63187-335; 63187-343; 63187-729; 65862-015; 65862-016; 65862-070; 68071-2320; 68071-2911; 70518-3228; 76420-573; 80425-0269; 0093-3109; 0093-4155; 50090-1513; 50090-1813; 50090-2251; 50090-6349; 57237-031; 61919-994; 63629-7585; 67296-1126; 68071-1826; 68788-6369; 68788-7323; 68788-8352; 68788-9019; 72189-463; 72789-225; 0781-6157; 81964-205; 83112-031; 0093-2263; 42571-233; 0143-9887; 50090-1826; 50090-6319; 50090-6355; 50436-0031; 53002-2091; 57237-033; 68071-3235; 68788-7414; 68788-9017; 68788-9949; 70934-064; 71205-775; 72189-285; 0781-2020; 76420-138; 82982-022; 0093-3107; 42708-078; 43063-915; 0143-9889; 50090-0302; 50090-0303; 50090-0405; 50090-0709; 50090-1811; 50090-6323; 57237-030; 59115-041
UNII 804826J2HU
Synonyms Amoxicillin | Amoxycillin | Amoxicilline | Amoxicillin Monopotassium Salt | Hydroxyampicillin | Amoxicillin Sodium | Amoxicillin Monosodium Salt | Amoxicillin, (R*)-Isomer | Amoxicillin Anhydrous | Actimoxi | BRL-2333 | BRL 2333 | BRL2333 | Clamoxyl | Penamox | Clamoxyl Parenteral | Clamoxyl G.A. | Polymox | Trimox | Wymox | Amoxicillin Trihydrate | Amoxil
Chemical Information
Molecular Formula C16H19N3O5S
CAS Registry Number 26787-78-0
SMILES CC1(C(N2C(S1)C(C2=O)NC(=O)C(C3=CC=C(C=C3)O)N)C(=O)O)C
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Subacute hepatic failure09.01.03.0110.000007%Not Available
Palatal oedema07.05.04.0080.000051%Not Available
Eosinophilic colitis07.08.01.019; 01.02.04.0150.000005%Not Available
Embolia cutis medicamentosa24.01.01.030; 12.07.03.052; 08.02.03.0520.000005%Not Available
Binocular eye movement disorder17.02.05.052; 06.05.02.0170.000010%Not Available
Pruritus allergic23.03.12.010; 10.01.03.0460.000005%Not Available
Genital erosion21.10.05.0150.000005%Not Available
Tongue exfoliation07.14.02.0200.000010%Not Available
Asthmatic crisis22.03.01.0180.000022%Not Available
Weight bearing difficulty15.03.05.0340.000005%Not Available
Abdominal wall haematoma24.07.02.039; 07.16.05.0050.000005%Not Available
Apparent death08.01.03.0620.000007%Not Available
Segmented hyalinising vasculitis24.12.04.023; 23.06.02.009; 10.02.02.0270.000005%Not Available
Skin plaque23.03.03.0440.000010%Not Available
Hyperlipasaemia14.11.01.0230.000010%Not Available
Foetal hypokinesia18.03.02.0150.000005%Not Available
Penile erythema21.12.01.0170.000005%Not Available
Band sensation17.16.01.0040.000012%Not Available
Crystal nephropathy20.05.03.016; 14.11.01.0350.000062%Not Available
Dropped head syndrome17.05.03.015; 15.05.06.0020.000005%Not Available
Chronic pigmented purpura24.07.06.021; 01.01.04.010; 23.06.01.0130.000007%Not Available
Chronic spontaneous urticaria23.04.02.011; 10.01.06.011--Not Available
Fine motor skill dysfunction17.01.02.020--Not Available
Pharyngeal paraesthesia22.04.05.018; 17.02.06.035--Not Available
Tongue discomfort07.14.02.0190.000011%Not Available
Administration site extravasation12.07.04.019; 08.02.04.0190.000010%Not Available
Administration site joint erythema23.03.06.022; 15.01.02.010; 12.07.04.025; 08.02.04.0250.000005%Not Available
Allergy to animal10.01.03.051--Not Available
Attention deficit hyperactivity disorder19.21.04.0040.000005%Not Available
Cerebral venous sinus thrombosis24.01.04.021; 17.08.03.0060.000005%Not Available
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ADReCS-Target
Drug Name ADR Term Target
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