Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Apixaban
Drug ID BADD_D00151
Description Apixaban is an oral, direct, and highly selective factor Xa (FXa) inhibitor of both free and bound FXa, as well as prothrombinase, independent of antithrombin III for the prevention and treatment of thromboembolic diseases[Label,A6897]. It is marketed under the name Eliquis[Label,L6043]. Apixaban was approved by the FDA on December 28, 2012[L6043].
Indications and Usage Apixaban is indicated for reducing the risk of stroke and systemic embolism in patients who have nonvalvular atrial fibrillation, prophylaxis of deep vein thrombosis(DVT) leading to pulmonary embolism(PE) in patients after a hip or knee replacement surgery, and treatment of DVT and PE to reduce the risk of recurrence[Label,A177565,A6897].
Marketing Status approved
ATC Code B01AF02
DrugBank ID DB06605
KEGG ID D03213
MeSH ID C522181
PubChem ID 10182969
TTD Drug ID D0I5HF
NDC Product Code 0003-0893; 52048-0420; 69037-0023; 76397-007; 15308-1221; 24196-190; 58032-2028; 66174-0091; 50193-0893; 65372-1196; 65727-081; 0003-3764; 55154-0612; 59651-051; 70366-001; 14445-149; 12783-0893; 12783-0894; 17381-026; 42765-025; 42816-0894; 58623-0137; 63850-8085; 65129-1344; 66039-925; 66651-921; 69989-0006; 63629-7747; 12658-0440; 53869-0893; 73377-191; 55154-0613; 70518-1861; 71610-662; 67835-0015; 75945-060; 76397-010; 50090-6454; 82982-054; 14501-0089; 16436-0113; 65129-1465; 63629-8432; 14445-014; 53747-062; 53869-0894; 63415-0520; 65015-897; 76072-1017; 14445-150; 42816-0893; 0003-0894; 55111-980; 50090-6451
UNII 3Z9Y7UWC1J
Synonyms apixaban | Eliquis | BMS 562247 | BMS562247 | BMS-562247-01 | BMS-562247
Chemical Information
Molecular Formula C25H25N5O4
CAS Registry Number 503612-47-3
SMILES COC1=CC=C(C=C1)N2C3=C(CCN(C3=O)C4=CC=C(C=C4)N5CCCCC5=O)C(=N2)C(=O)N
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Biliary obstruction09.02.02.0050.000065%Not Available
Blood loss anaemia24.07.01.088; 01.03.02.0180.000855%Not Available
BRASH syndrome14.05.03.005; 02.03.02.0300.000087%Not Available
Cerebellar stroke24.04.06.046; 17.08.01.0700.000065%Not Available
Cerebral mass effect17.11.01.0190.000586%Not Available
Cerebral venous sinus thrombosis24.01.04.021; 17.08.03.0060.000239%Not Available
Cerebrospinal fluid retention17.07.02.0100.000043%Not Available
Cholesteatoma16.02.03.001; 04.03.01.0160.000043%Not Available
Chronic gastrointestinal bleeding24.07.02.062; 07.12.02.0090.000087%Not Available
Colorectal adenoma16.05.02.009; 07.20.01.0190.000065%Not Available
Congestive hepatopathy02.05.04.018; 09.01.06.0270.000087%Not Available
Discoloured vomit07.01.07.0170.000108%Not Available
Dry age-related macular degeneration06.09.03.0300.000043%Not Available
Duodenal vascular ectasia24.03.03.046; 07.15.04.0080.000043%Not Available
Eosinophilic pleural effusion22.05.02.009; 01.02.04.0230.000043%Not Available
Eye haematoma24.07.05.017; 12.01.04.034; 06.07.02.0090.000065%Not Available
Gait inability17.02.05.069; 08.01.02.011--Not Available
Gastrointestinal angiectasia24.03.03.048; 07.15.04.0090.000065%Not Available
Gastrointestinal polyp16.05.01.007; 07.20.01.0220.000174%Not Available
Gastrointestinal vascular malformation haemorrhagic24.07.02.064; 07.15.04.0100.000065%Not Available
Giant cell arteritis24.12.02.003; 17.08.02.033; 10.02.02.032; 06.07.02.0100.000108%Not Available
Haematoma muscle24.07.01.091; 15.05.03.036; 12.01.07.0150.000594%Not Available
Haemoperitoneum12.01.17.007; 07.07.02.007; 24.07.02.0650.000586%Not Available
Haemorrhagic cholecystitis09.03.01.008; 24.07.01.0940.000152%Not Available
Haemorrhagic vasculitis10.02.02.033; 01.01.04.012; 24.12.04.012; 23.06.01.0150.000043%Not Available
Heavy menstrual bleeding21.01.03.0050.002863%Not Available
Hepatic cytolysis09.01.07.0360.000369%Not Available
Hepatic haemangioma rupture24.07.01.096; 16.06.01.005; 09.04.01.0050.000108%Not Available
Hyperleukocytosis01.02.01.0180.000043%Not Available
Hypersensitivity pneumonitis22.01.01.027; 10.01.03.0560.000087%Not Available
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