Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Apixaban
Drug ID BADD_D00151
Description Apixaban is an oral, direct, and highly selective factor Xa (FXa) inhibitor of both free and bound FXa, as well as prothrombinase, independent of antithrombin III for the prevention and treatment of thromboembolic diseases[Label,A6897]. It is marketed under the name Eliquis[Label,L6043]. Apixaban was approved by the FDA on December 28, 2012[L6043].
Indications and Usage Apixaban is indicated for reducing the risk of stroke and systemic embolism in patients who have nonvalvular atrial fibrillation, prophylaxis of deep vein thrombosis(DVT) leading to pulmonary embolism(PE) in patients after a hip or knee replacement surgery, and treatment of DVT and PE to reduce the risk of recurrence[Label,A177565,A6897].
Marketing Status approved
ATC Code B01AF02
DrugBank ID DB06605
KEGG ID D03213
MeSH ID C522181
PubChem ID 10182969
TTD Drug ID D0I5HF
NDC Product Code 0003-0893; 52048-0420; 69037-0023; 76397-007; 15308-1221; 24196-190; 58032-2028; 66174-0091; 50193-0893; 65372-1196; 65727-081; 0003-3764; 55154-0612; 59651-051; 70366-001; 14445-149; 12783-0893; 12783-0894; 17381-026; 42765-025; 42816-0894; 58623-0137; 63850-8085; 65129-1344; 66039-925; 66651-921; 69989-0006; 63629-7747; 12658-0440; 53869-0893; 73377-191; 55154-0613; 70518-1861; 71610-662; 67835-0015; 75945-060; 76397-010; 50090-6454; 82982-054; 14501-0089; 16436-0113; 65129-1465; 63629-8432; 14445-014; 53747-062; 53869-0894; 63415-0520; 65015-897; 76072-1017; 14445-150; 42816-0893; 0003-0894; 55111-980; 50090-6451
UNII 3Z9Y7UWC1J
Synonyms apixaban | Eliquis | BMS 562247 | BMS562247 | BMS-562247-01 | BMS-562247
Chemical Information
Molecular Formula C25H25N5O4
CAS Registry Number 503612-47-3
SMILES COC1=CC=C(C=C1)N2C3=C(CCN(C3=O)C4=CC=C(C=C4)N5CCCCC5=O)C(=N2)C(=O)N
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Hypertensive urgency24.08.01.0050.000108%Not Available
Idiopathic interstitial pneumonia22.01.02.031; 10.02.01.0800.000130%Not Available
Immune thrombocytopenia01.08.01.013; 10.02.01.0830.000412%Not Available
Implant site haematoma24.07.01.097; 12.07.02.044; 08.02.02.0440.000234%Not Available
Implant site haemorrhage24.07.01.098; 12.07.02.045; 08.02.02.0450.000043%Not Available
Intermenstrual bleeding21.01.01.015--Not Available
Lip erythema07.05.05.028--Not Available
Medical device site haemorrhage24.07.01.101; 08.07.01.029; 12.02.21.0130.000161%Not Available
Neovascular age-related macular degeneration06.09.03.0330.000065%Not Available
Normocytic anaemia01.03.02.0220.000043%Not Available
Oral purpura24.07.06.032; 07.05.02.005; 01.01.04.0140.000148%Not Available
Phrenic nerve paralysis17.01.04.0240.000087%Not Available
Physical deconditioning08.01.03.0960.000065%Not Available
Prosthetic cardiac valve thrombosis27.01.01.004; 24.01.05.015; 08.07.07.003; 02.07.02.0140.000087%Not Available
Pulpless tooth07.09.12.0020.000043%Not Available
Right atrial enlargement02.04.02.0490.000043%Not Available
Spinal stenosis17.10.01.031; 15.10.04.0140.000343%Not Available
Spinal subarachnoid haemorrhage24.07.04.037; 17.08.01.076; 12.01.13.0100.000065%Not Available
Spontaneous hyphaema24.07.05.021; 06.07.04.0020.000065%Not Available
Subcapsular hepatic haematoma09.01.06.031; 24.07.01.105; 12.01.17.0220.000043%Not Available
Subcapsular renal haematoma24.07.07.006; 20.01.02.021; 12.01.05.0080.000282%Not Available
Subgaleal haematoma24.07.01.106; 18.04.19.001; 12.01.09.0240.000065%Not Available
Superficial vein thrombosis24.01.02.0160.000377%Not Available
Therapeutic product ineffective08.06.01.0570.000065%Not Available
Thrombophlebitis migrans24.01.01.043; 16.32.01.0160.000217%Not Available
Treatment noncompliance12.09.02.006; 08.06.01.0670.006751%Not Available
Urinary tract neoplasm20.08.01.018; 16.08.03.0030.000043%Not Available
Uveal melanoma16.34.04.003; 06.12.04.0030.000043%Not Available
Vertebrobasilar artery dissection17.08.06.006; 24.02.04.0080.000065%Not Available
Vertebrobasilar stroke24.04.06.051; 17.08.01.0790.000043%Not Available
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