Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Apomorphine
Drug ID BADD_D00152
Description Apomorphine is a non-ergoline dopamine D2 agonist indicated to treat hypomobility associated with Parkinson's. It was first synthesized in 1845 and first used in Parkinson's disease in 1884.[A203618] Apomorphine has also been investigated as an emetic, a sedative, a treatment for alcoholism, and a treatment of other movement disorders.[A203597,A203618] Apomorphine was granted FDA approval on 20 April 2004.[L13919]
Indications and Usage Apomorphine is indicated to treat acute, intermittent treatment of hypomobility, off episodes associated with advanced Parkinson's disease.[L13919,L13922]
Marketing Status approved; investigational
ATC Code G04BE07; N04BC07
DrugBank ID DB00714
KEGG ID D07460
MeSH ID D001058
PubChem ID 6005
TTD Drug ID D0H6QU
NDC Product Code Not Available
UNII N21FAR7B4S
Synonyms Apomorphine | Apomorphine Hydrochloride, Anhydrous | Apomorphine Hydrochloride Anhydrous | Apomorphine Hydrochloride | Apomorphin-Teclapharm | Apomorphin Teclapharm | Apomorphine Hydrochloride, Hemihydrate | Apokinon | Apomorphine Chloride | Britaject
Chemical Information
Molecular Formula C17H17NO2
CAS Registry Number 58-00-4
SMILES CN1CCC2=C3C1CC4=C(C3=CC=C2)C(=C(C=C4)O)O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Dyspnoea22.02.01.004; 02.11.05.003--
Dystonia17.01.03.0010.000582%Not Available
Ecchymosis24.07.06.002; 23.06.01.001; 01.01.03.001--Not Available
Eosinophilia01.02.04.0010.000273%
Epilepsy17.12.03.0020.000182%Not Available
Erythema23.03.06.0010.000364%Not Available
Fatigue08.01.01.002--
Feeling abnormal08.01.09.0140.000709%Not Available
Feeling hot08.01.09.0090.000618%Not Available
Flatulence07.01.04.0020.000182%
Flushing08.01.03.025; 24.03.01.002; 23.06.05.0030.000400%
Granuloma23.03.15.001; 08.01.05.001--Not Available
Haemolysis01.06.04.0020.000182%
Haemolytic anaemia01.06.03.0020.001546%Not Available
Hallucination19.10.04.0030.003237%
Hallucination, visual19.10.04.0070.000182%Not Available
Headache17.14.01.001--
Hyperhidrosis23.02.03.004; 08.01.03.0280.001418%
Hypersensitivity10.01.03.0030.000491%
Hypertension24.08.02.0010.000800%
Hyperventilation22.02.01.006; 19.01.02.0040.000182%Not Available
Hypotension24.06.03.0020.002982%
Hypotonia17.05.02.002; 15.05.04.0080.000182%Not Available
Ileus07.13.01.0010.000182%
Incontinence20.02.02.004; 17.05.01.006; 07.01.06.0110.000400%Not Available
Influenza like illness08.01.03.0100.000400%
Injection site bruising24.07.06.017; 23.03.11.015; 12.07.03.042; 08.02.03.0420.001509%Not Available
Injection site erythema23.03.06.015; 12.07.03.001; 08.02.03.0010.001600%Not Available
Injection site haemorrhage24.07.01.010; 12.07.03.005; 08.02.03.0050.000709%Not Available
Injection site induration12.07.03.007; 08.02.03.0070.000491%Not Available
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ADReCS-Target
Drug Name ADR Term Target
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