Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Apomorphine
Drug ID BADD_D00152
Description Apomorphine is a non-ergoline dopamine D2 agonist indicated to treat hypomobility associated with Parkinson's. It was first synthesized in 1845 and first used in Parkinson's disease in 1884.[A203618] Apomorphine has also been investigated as an emetic, a sedative, a treatment for alcoholism, and a treatment of other movement disorders.[A203597,A203618] Apomorphine was granted FDA approval on 20 April 2004.[L13919]
Indications and Usage Apomorphine is indicated to treat acute, intermittent treatment of hypomobility, off episodes associated with advanced Parkinson's disease.[L13919,L13922]
Marketing Status approved; investigational
ATC Code G04BE07; N04BC07
DrugBank ID DB00714
KEGG ID D07460
MeSH ID D001058
PubChem ID 6005
TTD Drug ID D0H6QU
NDC Product Code Not Available
UNII N21FAR7B4S
Synonyms Apomorphine | Apomorphine Hydrochloride, Anhydrous | Apomorphine Hydrochloride Anhydrous | Apomorphine Hydrochloride | Apomorphin-Teclapharm | Apomorphin Teclapharm | Apomorphine Hydrochloride, Hemihydrate | Apokinon | Apomorphine Chloride | Britaject
Chemical Information
Molecular Formula C17H17NO2
CAS Registry Number 58-00-4
SMILES CN1CCC2=C3C1CC4=C(C3=CC=C2)C(=C(C=C4)O)O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Pruritus23.03.12.001--
Pyrexia08.05.02.0030.000636%
Respiratory disorder22.02.07.0020.000182%Not Available
Restlessness17.02.05.021; 19.11.02.0020.000618%
Rhinorrhoea22.12.03.0210.001546%
Shock24.06.02.002--Not Available
Skin necrosis23.03.03.0110.000455%Not Available
Skin reaction23.03.03.013; 10.01.03.0190.000182%Not Available
Skin ulcer24.04.03.007; 23.07.03.0030.000182%
Sleep disorder19.02.04.0010.000491%Not Available
Sneezing22.12.03.0240.000618%
Somnolence19.02.05.003; 17.02.04.0060.004964%
Swelling08.01.03.015--Not Available
Syncope02.11.04.015; 24.06.02.012; 17.02.04.0080.000491%
Thinking abnormal19.10.03.001; 17.02.05.0230.000618%Not Available
Tremor17.01.06.0020.001509%
Unresponsive to stimuli17.02.05.0310.000182%Not Available
Urinary tract infection20.08.02.001; 11.01.14.004--
Vision blurred17.17.01.010; 06.02.06.0070.000618%
Vomiting07.01.07.0030.005364%
Yawning22.12.03.0370.001509%Not Available
Peripheral swelling08.01.03.053; 02.05.04.0150.000927%Not Available
General physical health deterioration08.01.03.0180.000455%Not Available
Contusion15.03.05.007; 24.07.06.001; 23.03.11.002; 12.01.06.001--
Musculoskeletal discomfort15.03.04.001--Not Available
Nodule08.03.05.0020.000909%Not Available
Injection site nodule08.02.03.034; 23.07.04.009; 12.07.03.0340.001346%Not Available
Disturbance in sexual arousal19.08.04.003--Not Available
Hot flush24.03.01.005; 21.02.02.001; 08.01.03.0270.000618%
Inflammation10.02.01.089; 08.01.05.0070.000182%Not Available
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ADReCS-Target
Drug Name ADR Term Target
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