Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Apraclonidine hydrochloride
Drug ID BADD_D00155
Description Apraclonidine, also known as iopidine, is a sympathomimetic used in glaucoma therapy. It is an alpha2-adrenergic agonist.
Indications and Usage For prevention or reduction of intraoperative and postoperative increases in intraocular pressure (IOP) before and after ocular laser surgery when used prophylactically. Also used as a short-term adjunctive therapy in patients with open-angle glaucoma who are on maximally tolerated medical therapy requiring additional IOP reduction.
Marketing Status approved
ATC Code S01EA03
DrugBank ID DB00964
KEGG ID D01008
MeSH ID C016986
PubChem ID 51763
TTD Drug ID D0MT0M
NDC Product Code 58567-103; 51014-7782; 17478-716
UNII D2VW67N38H
Synonyms apraclonidine | 4-aminoclonidine | para-aminoclonidine | 2-(4-amino-2,6-dichloro)phenyliminoimidazolidine | p-aminoclonidine | apraclonidine hydrochloride | Iopidine | Iopimax | ALO 2145 | ALO-2145
Chemical Information
Molecular Formula C9H11Cl3N4
CAS Registry Number 73218-79-8
SMILES C1CN=C(N1)NC2=C(C=C(C=C2Cl)N)Cl.Cl
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal discomfort07.01.06.001--Not Available
Abdominal pain07.01.05.002--
Abnormal dreams19.02.03.001; 17.15.02.001--Not Available
Bradycardia02.03.02.002--Not Available
Burning sensation17.02.06.001; 08.01.09.029--Not Available
Chest discomfort02.02.02.009; 22.12.02.002; 08.01.08.019--Not Available
Chest pain22.12.02.003; 08.01.08.002; 02.02.02.011--Not Available
Cold sweat23.02.03.002; 08.01.03.024--Not Available
Conjunctival haemorrhage24.07.05.001; 06.07.01.001--Not Available
Diarrhoea07.02.01.001--
Discomfort08.01.08.003--Not Available
Dry mouth07.06.01.002--
Dry skin23.03.03.001--
Dysgeusia17.02.07.003; 07.14.03.001--
Dyspnoea02.11.05.003; 22.02.01.004--
Eye inflammation06.04.05.002--Not Available
Fatigue08.01.01.002--
Feeling hot08.01.09.009--Not Available
Headache17.14.01.001--
Heart rate irregular13.14.04.003--Not Available
Hypoaesthesia23.03.03.081; 17.02.06.023--Not Available
Hypotonia17.05.02.002; 15.05.04.008--Not Available
Insomnia17.15.03.002; 19.02.01.002--
Irritability19.04.02.013; 08.01.03.011--
Libido decreased21.03.02.005; 19.08.03.001--
Mydriasis17.02.11.003; 06.05.03.004--Not Available
Nasal dryness22.04.03.002--Not Available
Ocular hyperaemia06.04.05.004--Not Available
Pain in extremity15.03.04.010--
Palpitations02.11.04.012--
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