Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Apraclonidine hydrochloride
Drug ID BADD_D00155
Description Apraclonidine, also known as iopidine, is a sympathomimetic used in glaucoma therapy. It is an alpha2-adrenergic agonist.
Indications and Usage For prevention or reduction of intraoperative and postoperative increases in intraocular pressure (IOP) before and after ocular laser surgery when used prophylactically. Also used as a short-term adjunctive therapy in patients with open-angle glaucoma who are on maximally tolerated medical therapy requiring additional IOP reduction.
Marketing Status approved
ATC Code S01EA03
DrugBank ID DB00964
KEGG ID D01008
MeSH ID C016986
PubChem ID 51763
TTD Drug ID D0MT0M
NDC Product Code 58567-103; 51014-7782; 17478-716
UNII D2VW67N38H
Synonyms apraclonidine | 4-aminoclonidine | para-aminoclonidine | 2-(4-amino-2,6-dichloro)phenyliminoimidazolidine | p-aminoclonidine | apraclonidine hydrochloride | Iopidine | Iopimax | ALO 2145 | ALO-2145
Chemical Information
Molecular Formula C9H11Cl3N4
CAS Registry Number 73218-79-8
SMILES C1CN=C(N1)NC2=C(C=C(C=C2Cl)N)Cl.Cl
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Paraesthesia23.03.03.094; 17.02.06.005--
Presyncope02.11.04.013; 24.06.02.010; 17.02.05.009--
Pruritus23.03.12.001--
Vision blurred17.17.01.010; 06.02.06.007--
Vomiting07.01.07.003--
Nasal discomfort22.12.03.012--Not Available
Nasal decongestion therapy25.05.03.003--Not Available
Blood pressure orthostatic13.14.03.023--Not Available
Biopsy eyelid abnormal13.18.02.002--Not Available
Sensation of foreign body08.01.09.002--Not Available
Increased upper airway secretion22.12.03.007--Not Available
Conjunctival pallor06.07.01.004; 01.03.02.015--Not Available
Cold-stimulus headache17.14.01.014--Not Available
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