Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Aripiprazole
Drug ID BADD_D00165
Description Aripiprazole is an atypical antipsychotic orally indicated for treatment of schizophrenia, bipolar I, major depressive disorder, irritability associated with autism, and Tourette's[Label]. It is also indicated as an injection for agitation associated with schizophrenia or bipolar mania[Label]. Aripiprazole exerts its effects through agonism of dopaminic and 5-HT1A receptors and antagonism of alpha adrenergic and 5-HT2A receptors[Label,A4393]. Aripiprazole was given FDA approval on November 15, 2002[L6136].
Indications and Usage For the treatment of schizophrenia and related psychotic disorders.
Marketing Status Prescription; Discontinued
ATC Code N05AX12
DrugBank ID DB01238
KEGG ID D01164
MeSH ID D000068180
PubChem ID 60795
TTD Drug ID D0H3HM
NDC Product Code 48433-120; 59148-007; 68554-0095; 62332-099; 60505-2675; 59148-010; 76282-045; 68382-439; 27241-056; 71335-1903; 31722-829; 63629-7017; 46708-256; 16714-787; 60505-2674; 17856-0570; 59651-110; 43598-554; 70518-3380; 48433-115; 65862-662; 65862-680; 50090-4817; 65162-896; 33342-123; 70518-2565; 68788-7162; 13668-219; 76282-049; 71335-1980; 60429-451; 0904-6511; 0904-6656; 31722-820; 50370-0009; 48433-117; 16714-145; 50090-4160; 68554-0020; 55289-251; 70934-662; 59148-030; 43353-148; 46602-0045; 67877-432; 63629-7003; 46708-260; 68071-5062; 50370-0044; 70518-2508; 71335-1893; 42043-401; 27241-052; 50228-325; 68788-7733; 50090-4800; 46602-1031; 63739-413; 72865-185; 43547-304; 0904-6510; 43598-966; 59148-034; 70771-1454; 43547-303; 71335-0412; 27241-053; 60687-157; 29300-176; 43598-968; 76282-048; 43598-558; 59116-2901; 70771-1451; 46602-1029; 59148-018; 68382-083; 67877-433; 43547-306; 70518-1303; 50228-477; 69452-339; 68788-7808; 16729-279; 65162-902; 63415-0085; 70518-2765; 59148-011; 50228-324; 27241-054; 12828-0088; 70771-1456; 29300-178; 50090-5840; 67877-434; 43598-970; 50228-478; 62332-100; 50090-5839; 33342-126; 60505-2677; 46602-1032; 46602-0010; 31722-827; 72865-153; 72865-181; 53104-7628; 59148-045; 43598-967; 70518-2806; 46602-0006; 68788-7006; 46602-0026; 59148-029; 43598-555; 64220-112; 70518-2950; 33342-124; 50228-329; 70518-2584; 50090-4863; 16714-788; 60687-168; 70518-2869; 60505-2673; 13668-221; 43547-305; 43353-140; 72865-154; 16714-783; 72865-184; 33342-127; 62332-098; 71335-1935; 65862-666; 13668-216; 16729-280; 43353-180; 68382-085; 29300-179; 16714-141; 63629-6999; 65162-899; 65862-661; 43598-969; 0904-6514; 70518-2580; 16714-144; 70518-2567; 70518-2825; 70518-2736; 16714-146; 46602-0007; 66689-735; 58032-2005; 59148-072; 13668-217; 60429-446; 59148-032; 63187-965; 31722-830; 71335-1364; 65372-1121; 62332-097; 63739-070; 70518-2515; 16714-785; 50228-328; 70518-2536; 72865-183; 62332-101; 70518-2557; 0615-8375; 65862-663; 72865-182; 33342-122; 60505-2676; 43598-556; 71335-1682; 46602-0072; 50090-3941; 46602-0009; 43598-559; 46708-259; 68382-082; 50090-4936; 65691-0052; 43547-302; 46602-0008; 71205-480; 43598-965; 68382-084; 60429-449; 43547-307; 71335-1832; 71335-1515; 17856-0110; 50370-0055; 59148-006; 53747-031; 50228-327; 60505-3075; 50268-088; 70518-1263; 70518-2820; 13668-218; 50228-476; 72865-158; 50090-4665; 16729-278; 16714-786; 59148-008; 70518-2897; 72761-020; 68788-8089; 31722-819; 68788-7076; 65862-664; 70518-3011; 60687-213; 46602-0011; 72865-157; 29300-180; 76072-1002; 70518-2921; 46602-1030; 16729-282; 62332-102; 76282-047; 65841-140; 71335-1688; 70771-1455; 71335-1513; 46708-254; 48433-119; 60429-450; 65162-898; 60505-0404; 43353-147; 59148-031; 63739-074; 70771-1452; 46708-258; 0904-6509; 46708-255; 65162-897; 50268-091; 27241-051; 59148-019; 46602-1034; 76282-046; 46602-1033; 12658-0576; 0615-8259; 48433-118; 72865-155; 50228-480; 62332-103; 68788-7063; 0904-6512; 27241-055; 63629-7108; 50268-089; 53808-1101; 63739-078; 70518-3004; 68382-086; 70518-1421; 72865-180; 70518-2827; 50268-092; 16729-283; 66603-706; 68071-2394; 69452-338; 16729-281; 12658-0577; 70518-2514; 67877-431; 72865-156; 49706-1889; 68788-7749; 65862-665; 50268-087; 70518-2958; 69037-0058; 50228-475; 33342-125; 58623-0127; 63739-069; 70771-1453; 60429-447; 14445-019; 60429-448; 43598-557; 66603-705; 76282-044; 46602-0025; 50268-090; 71335-1687; 29300-177; 67835-0009; 31722-828; 71335-1892; 46708-261; 54838-570; 70518-0970; 60687-202; 71205-392; 63629-7774; 70518-3090; 67877-430; 16714-784; 29300-175; 70518-2974; 16714-143; 60687-179; 59148-033; 62332-104; 67877-435; 42043-400; 65096-0107; 13668-220; 16714-142; 46708-257; 50228-326; 48433-116; 65162-893; 59148-009; 50228-479; 0904-6513; 60687-191; 65162-901; 59116-2900; 71335-1711; 70518-2643
Synonyms Aripiprazole | 7-(4-(4-(2,3-dichlorophenyl)-1-piperazinyl)butyloxy)-3,4-dihydro-2(1H)-quinolinone | Aripiprazol | Abilify | OPC 14597 | OPC-14597
Chemical Information
Molecular Formula C23H27Cl2N3O2
CAS Registry Number 129722-12-9
SMILES C1CC(=O)NC2=C1C=CC(=C2)OCCCCN3CCN(CC3)C4=C(C(=CC=C4)Cl)Cl
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Arrhythmia02.03.02.0010.004005%Not Available
Arthralgia15.01.02.001--
Arthritis15.01.01.001--
Arthropathy15.01.01.003--Not Available
Arthropod bite12.01.08.022--Not Available
Aspartate aminotransferase increased13.03.01.006--
Asphyxia22.02.02.001; 12.01.08.0110.000100%Not Available
Asthenia08.01.01.001--Not Available
Asthma10.01.03.010; 22.03.01.002--Not Available
Ataxia17.02.02.001; 08.01.02.0040.005721%
Atrial fibrillation02.03.03.002--
Atrial flutter02.03.03.003--
Atrial tachycardia02.03.03.0040.000381%
Atrioventricular block02.03.01.0020.000763%Not Available
Atrioventricular block complete02.03.01.0030.000572%
Atrioventricular block first degree02.03.01.0040.000381%
Atrioventricular block second degree02.03.01.0050.000954%
Attention deficit/hyperactivity disorder19.21.04.0010.001526%Not Available
Axonal neuropathy17.09.03.0150.000572%Not Available
Azoospermia21.03.03.0010.000381%
Azotaemia20.01.01.001--Not Available
Back pain15.03.04.005--
Basedow's disease06.09.04.003; 05.02.02.003; 10.04.08.0040.000381%Not Available
Benign prostatic hyperplasia21.04.02.001--Not Available
Bile duct stone09.02.02.0030.000381%Not Available
Binge eating19.09.01.0010.001716%Not Available
Bipolar I disorder19.16.01.0020.000763%Not Available
Bladder dilatation20.03.01.0070.000381%Not Available
Bladder discomfort20.02.02.019--Not Available
Bladder pain20.02.02.001--Not Available
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