Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Aztreonam
Drug ID BADD_D00206
Description A monocyclic beta-lactam antibiotic originally isolated from Chromobacterium violaceum. It is resistant to beta-lactamases and is used in gram-negative infections, especially of the meninges, bladder, and kidneys. It may cause a superinfection with gram-positive organisms.
Indications and Usage For the treatment of the following infections caused by susceptible gram-negative microorganisms: urinary tract infections, lower respiratory tract infections, septicemia, skin and skin-structure infections, intra-abdominal infections, and gynecologic infections.
Marketing Status approved
ATC Code J01DF01
DrugBank ID DB00355
KEGG ID D00240
MeSH ID D001398
PubChem ID 2274
TTD Drug ID D0F2XV
NDC Product Code 24525-0025; 13538-001; 0409-0830; 54087-160; 63323-401; 63323-402; 52952-001; 0003-2570; 0003-2560; 73301-008; 13538-008; 61958-0901; 0409-0829; 13538-009
UNII G2B4VE5GH8
Synonyms Aztreonam | Az-threonam | Az threonam | Azthreonam | SQ-26,776 | SQ 26,776 | SQ26,776 | Urobactam | Azactam
Chemical Information
Molecular Formula C13H17N5O8S2
CAS Registry Number 78110-38-0
SMILES CC1C(C(=O)N1S(=O)(=O)O)NC(=O)C(=NOC(C)(C)C(=O)O)C2=CSC(=N2)N
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Dizziness02.11.04.006; 24.06.02.007; 17.02.05.003--
Drug hypersensitivity10.01.01.0010.000559%Not Available
Drug ineffective08.06.01.0060.000267%Not Available
Dysgeusia17.02.07.003; 07.14.03.001--
Dyspnoea02.11.05.003; 22.02.01.0040.000156%
Eosinophil count increased13.01.06.004--Not Available
Eosinophilia01.02.04.001--
Erythema23.03.06.001--Not Available
Erythema multiforme23.03.01.003; 10.01.03.015--
Extrasystoles02.03.02.003--Not Available
Feeling abnormal08.01.09.014--Not Available
Flushing23.06.05.003; 08.01.03.025; 24.03.01.002--
Gastrointestinal haemorrhage24.07.02.009; 07.12.02.001--Not Available
Gastrointestinal pain07.01.05.005--
Haemoglobin13.01.05.018--Not Available
Headache17.14.01.001--
Hepatic failure09.01.03.002--
Hepatic function abnormal09.01.02.0010.000073%Not Available
Hepatitis09.01.07.004--Not Available
Hepatocellular injury09.01.07.0080.000097%Not Available
Hyperhidrosis23.02.03.004; 08.01.03.028--
Hypersensitivity10.01.03.003--
Hyperthermia08.05.01.001; 12.05.01.0020.000073%Not Available
Hypotension24.06.03.0020.000131%
Hypoxia22.02.02.0030.000049%
Insomnia19.02.01.002; 17.15.03.002--
Jaundice23.03.03.030; 09.01.01.004; 01.06.04.004--Not Available
Joint swelling15.01.02.004--Not Available
Laryngeal pain22.12.03.010--
Leukocytosis01.02.01.002--
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