| Drug Name |
Beclomethasone dipropionate monohydrate |
| Drug ID |
BADD_D00220 |
| Description |
Beclomethasone dipropionate is a second-generation synthetic corticosteroid agent [A179842] and a diester of beclomethasone, which is structurally similar to [dexamethasone].[L6871] It is a prodrug of an active metabolite beclomethasone 17-monopropionate (17-BMP)[A179839] which acts on the glucocorticoid receptor to mediates its therapeutic action. Beclomethasone dipropionate itself posesses weak glucocorticoid receptor binding affinity and is rapidly converted into 17-BMP upon administration.[A179839] Formulations for oral inhalation, intranasal, and topical use are available for beclomethasone dipropionate. Beclomethasone dipropionate became first available in a pressurized metered-dose inhaler in 1972 and later in a dry powder inhaler and an aqueous nasal spray.[A179839] Due to its anti-inflammatory, antipruritic, and anti-allergy properties, beclomethasone dipropionate is used in various inflammatory conditions, such as asthma, allergic rhinitis, and dermatoses to reduce symptoms. When inhaled, it is proposed that beclomethasone dipropionate remains active locally in the lung without causing significant side effects associated with systemic corticosteroids.[A180010] Compared to earlier corticosteroids such as [dexamethasone] and [prednisolone], beclomethasone dipropionate is reported to be less irritating to the nasal mucosa with a longer duration of action when administered intranasally.[A179848] |
| Indications and Usage |
Indicated for oral inhalation use in the maintenance treatment of asthma as prophylactic therapy in patients 5 years of age and older. The aerosol form of beclomethasone diproprionate is not indicated for the relief of acute bronchospasm.[L6871]
Indicated for intranasal use to relieve the symptoms of seasonal or perennial allergic and nonallergic (vasomotor) rhinitis and prevent the recurrence of nasal polyps following surgical removal.[L6880]
Indicated for the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses in patients 13 years of age and older.[L10782] Corticosteroid-responsive dermatoses include psoriasis, contact dermatitis (dermatitis venenata), atopic dermatitis (infantile eczema, allergic dermatitis), neurodermatitis (lichen simplex chronicus, lichen planus, eczema, eczematous dermatitis), intertrigo, dyshidroses (pompholyx), seborrheic dermatitis, exfoliative dermatitis, solar dermatitis, stasis dermatitis, and anogenital and senile pruritus.[L6886] |
| Marketing Status |
approved; investigational |
| ATC Code |
R01AD01; R03BA01; A07EA07; D07AC15 |
| DrugBank ID |
DB00394
|
| KEGG ID |
D11572
|
| MeSH ID |
D001507
|
| PubChem ID |
16052009
|
| TTD Drug ID |
D07DVK
|
| NDC Product Code |
46439-8748; 0173-0388 |
| UNII |
4H7L9AI22I
|
| Synonyms |
Beclomethasone | Beclometasone | Asmabec Clickhaler | Ascocortonyl | Beclamet | Beclo Asma | Beclo AZU | Beclocort | Beclomet | Bemedrex Easyhaler | Beclomethasone Dipropionate | Dipropionate, Beclomethasone | Beclorhinol | Sanasthmax | Becloturmant | Beclovent | Beconase | Becloforte | Becodisk | Becodisks | Propaderm | Becotide | Sanasthmyl | Beconase AQ | Bronchocort | Junik | Qvar | Ecobec | Beclazone | Beclazone Easy Breathe | Ventolair | Prolair | Filair | Filair Forte | AeroBec Forte | Aerobec | Nasobec Aqueous | Respocort | Vancenase | Vanceril | Aldecin | Viarin | Apo-Beclomethasone |
